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Expression of EGFR in human lung cancer tissues

Huang Yunchao,Yang Junjie, Zhou Qinghua, et al.Department of Thoracocardiac Surgery, The First University Hospital,West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R. China  
Objective To determine the expression of EGFR of lung cancer tissues and its clinical significance.Methods The expression of EGFR was detected in 95 primary lung cancer tissues and their para cancerous lung tissues and 39 benign pulmonary lesion tissues as control by immunohistochemical method.Results The positive rate of EGFR expression was 87.9%(80/91) in non small cell lung cancer (NSCLC) and 10.3%(4/39) in benign pulmonary tissues, but was 0% in 4 small cell lung cancer. The positive rate was 63.7%(58/91) in the paracancerous tissues from 0 to 3.0 cm outside the tumors,12.1%(11/91) from 3.0 to 6.0cm outside the tumors. Conclusion The positive rate of EGFR expression in lung cancer tissues was significantly higher than that in benign pulmonary tissues. Determinatation of EGFR expression might be useful to differentiate malignant from benign lesion of the lung.
【CateGory Index】: R734.2
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