Clinical pharmacokinetics of the same doses of carboplatin in different arterial chemotherapy ways for cervical cancer
WANG Wei;LIU Ping;CHEN Chun-lin;Department of Gynecology,Zhongshan People's Hospital;
Objective To observe the pharmacokinetics changes of the same doses of carboplatin in different arterial chemotherapy ways for cervical cancer and explore the effect of gelfoam particles. Methods Eighteen patients with locally advanced cervical cancer diagnosed by histopathology were randomly divided into two groups. Patients in group A were administered with carboplatin at the dosage of 400 mg/m~2 by infusing,and then embolized with gelfoam particles( 1 mm in diameter). Patients in group B were administered with carboplatin at the dosage of 300 mg/m~2 by infusing,and then embolized with the mixture of carboplatin at the dosage of 100 mg/m~2 and gelfoam particles( 1 mm in diameter). Carboplatin was administered by infusing into two groups respectively at the dosage of 400 mg/m~2. Tissues from the cervical cancer lesions were collected at different times( 0 h,0. 17 h,0. 33 h,0. 5 h,1 h,7 h,13 h,25 h and 49 h after infusion) of two groups and then analyzed by using atomic absorption spectrometry and calculate their pharmacokinetic parameters. Results( 1) The concentration-time curve of platinum in tumor tissues in two groups was of noncompartmental model. Thepeak value concentration of platinum in tumor tissues of the two groups were observed immediately after infusion,and then descended quickly. Another peak value of concentration of platinum in tumor tissue of two groups was observed between immediately and 6 hours after embolization and descended slowly.( 2) there was no significant difference of Cmax, Tmax, AUC( 0-49 h), t1/2, MRT, CL/F and Vd/F between the two groups. Conclusions In cervical cancer arterial chemotherapy, different arterial chemotherapy ways with the same dose of carboplatin does not affect the carboplatin's absorption,distribution,metabolism and excretion process,thus,gelfoam particles have no sustained-release effect.
【CateGory Index】： R737.33