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《Obstetrics-Gynecology and Genetics(Electronic Edition)》 2017-04
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The correlation between hyperemesis gravidarum and adverse perinatal outcomes: a meta-analysis

TANG Gui-yan;YANG Yi-lin;LUO Wan-jun;YUE Jiang-hua;PENG Ling-xiang;TANG Li-min;HUANG Qi-tao;Affiliated Hospital of Guilin Medical College;  
Objective To investigate the correlation between hyperemesis gravidarum and adverse perinatal outcomes. Methods Studies that relating to the correlation between hyperemesis gravidarum and adverse perinatal outcomes were searched in Pub Med, Web of Science, Cochrane,Embase,CNKI Data, Wan Fang Data and VIP Data etc.( from January 2011 to January 2017). The quality of included case-control studies or cohort studies was evaluated,and Meta-analysis was performed with Rev Man 5. 2 software. Results A total of 14 studies were included,involving 3 566 997 women in observation. Meta Analysis results display that the hyperemesis gravidarum will increase the risk of low birth weight infants( OR = 1. 45,95% CI: 1. 06 ~ 1. 97, P = 0. 02),small for gestational age( OR = 1. 27,95% CI: 1. 04 ~ 1. 57,P = 0. 02) and preterm( OR = 1. 29,95% CI: 1. 06 ~ 1. 57,P = 0. 01),but had no significant correlation with the incidence of neonatal Apgar score 7( 5 min), stillbirth, gestational diabetes and gestational hypertension or pre-eclampsia. Conclusions Hyperemesis gravidarum is associated with adverse perinatal outcomes such as low birth weight infants,small for gestational age and preterm,and should be monitored or treated in a timely manner to reduce the risk of adverse outcomes.
【CateGory Index】: R714.241
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