The corrletion between elevated maternal cytokines and schizophrenia: a meta analysis
LUO Wan-jun;YANG Yi-lin;WEN Yu-wen;YAN Xin-yue;WANG Qi-qiong;XU Ruo-ting;XIE Pei-jun;LIU Ci-di;ZHANG Jian;HUANG Qi-tao;ZHONG Mei;the Second Clinical School of Southern Medical University;;
Objective To determine whether elevated maternal cytokines are associated with increased risk of schizophrenia in adultoffspring. Methods We conducted a systematic literature search using the electronic databases Pub Med, Web of Science, Cochrane database, Embase, CNKI,Wanfang Data and VIP Data up to August 2017. Standard Median Difference( SMD) and 95%confidence interval( 95% CI) were calculated separately for each case group and Rev Man 5. 2 was used for all analyses. Results 5 case-control studies,involving 190 schizophrenia patients and 306 controls were identified. Pooled results suggest that increasing maternal IL-8 and IL-10 levels are associated with increased risk of schizophrenia in the offspring relative to controls( IL-8: SMD = 0. 29 pg/m L,95% CI:0. 10 ~ 0. 48, P = 0. 003; IL-10: SMD = 0. 62 pg/m L, 95% CI : 0. 33 ~ 0. 90, P 0. 0001).Conclusions Our study shows that the individuals with increasing maternal IL-8 and IL-10 may have elevated risk of schizophrenia. Therefore,the level of maternal IL-8 and IL-10 may have certain value inpredicting risk of schizophrenia in the offspring. The estimate of maternal cytokines may contribute to the identification of at-risk individuals and early interventions for schizophrenia.
【CateGory Index】： R714