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《Journal of Fudan University(Natural Science)》 2018-02
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Study on Hepatitis B Model with Drug Resistance

GUO Linna;SONG Yunna;Basic Medicine School,Qiqihar Medical College;  
By using the medication with non-compliance for long time and characteristics of HBV infection,HBV with drug resistance often occurs.A hepatitis B model of the lurker,acute patients and chronic patients with the sensibility or resistance was established.Non-negativity of the model was researched.And using the basic regeneration matrix,spectral radius and Lyapunov-Lasalles theorem,the sufficient conditions for the existence and stability of disease-free equilibrium point,boundary equilibrium point,and endemic equilibrium point of the model with resistance are discussed.The results show that reducing the parameter p1,p2 values and increasing the efficacy of drugs can control the dissemination of infectious diseases.The conclusion is verified through numerical simulation.
【Fund】: 齐齐哈尔医学院院内基金项目(QY2016M-10)
【CateGory Index】: R512.62
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