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Effects of antimicrobial peptide cecropin replacing colistin sulfate on the growth performance and diarrhea of weaned piglets

Sun Xuemei;Liang Weifan;Chen Chunping;Wang Daohao;Zhou Yuyan;  
The purpose of this experiment is to investigate the effects of antimicrobial peptide cecor-pin, replacing colistin sulfate in creep feed and nursery feed, on the growth performance and diarrheaof weaned piglets. In the experiment, a total of 240 weaned piglets with similar physiological statuswere randomly assigned into 4 groups with 3 replicates in each group, with 20 weaned piglets in eachreplicate. The control group was fed with basal diets supplemented with colistin sulfate, while group 1to group 3 were fed with basal diets supplemented with cecropin and encapsulated essential oil, cecro-pin, other antimicrobial peptide, respectively. The effect was evaluated by average daily gain(ADG),average daily feed intake(ADFI), feed conversion rate(FCR), diarrhea index, diarrhea rate in the stageof creep feed(0~14 d) and nursery feed(14~28 d). The results showed that an the stage of creep feed(0~14 d), there was no significant differenceamong four groups(P0.05). An the stage ofnursery feed(14~28 d), ADGs of group 1 andgroup 2 were significantly increased and diar-rhea index and diarrhea rate of that were signifi-cantly decreased compared with control group(P0.05). In the whole process of experiment(0~28 d),ADGs of group 1 and group 2 were significantly increased by 16.6% and 10.5%(P0.05)comparedwith control group, but FCRs were remain unchanged. Diarrhea index and diarrhea rate of group 1 andgroup 2 were significantly decreased(P0.05). Diarrhea indexs were both decreased by 36.4% and di-arrhea rates were decreased by 52.6% and 47.1%, respectively. FCR of group 3 was significantly in-creased by 12.4%(P0.05), while diarrhea index and diarrhea rate remained unchanged. In conclu-sion, supplementing with antimicrobial peptide cecorpin in the basal diets of creep feed and nurseryfeed can significantly increase ADGs and reduce diarrhea of weaned piglets compared with colistin sul-fate, while combined with cecorpin and encapsulated essential oil can gain better performance. Antimi-crobial peptide cecorpin is the ideal substitution of colistin sulfate.
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