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《Journal of Fisheries Research》 2018-03
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Research progress of marine natural active substances with lowering uric acid effects

ZHAO Yuxi;XIONG Hejian;WU Jingna;SU Yongchang;LIU Shuji;HE Chuanbo;LIU Zhiyu;College of Food and Biological Engineering,Jimei University;Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources,Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province,Fisheries Research Institute of Fujian;  
In recent years,the incidence of hyperuricemia and gout has risen,and the high level of uric acid often leads to rheumatism, cardiovascular and cerebrovascular diseases, renal dysfunction and a series of complications,which seriously impacts upon people's normal quality of life and social production. Compared with the western medicine currently used in clinical practice,active substances from natural resource get more attention because of the more moderate function,safer,no damage to the kidney,fewer side effect and so on. Various active substances from natural resource which have the uric acid-lowering efficacy reported currently were mainly polysaccharide,polyphenols,saponins,flavonoids,bioactive peptides,etc. This paper reviewed the synthetic pathways of uric acid and the enzymes that play an important role in purine metabolism in human body( such as xanthine oxidase,adenosine deaminase,etc.),uric acid excretion pathway and main influencing factors,the pathogenesis of high uric acid and the reasons for the imbalance of purine metabolism,the common evaluation model of uric acid-lowing,and the research progress of marine natural active substances that have effects of lowering uric acid. And we hoped to provide a reference for the development of functional food with the effect of reducing uric acid.
【Fund】: 福建省省属类科研院所专项(2017R1003-10)
【CateGory Index】: R284.1
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