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《Rheumatism and Arthritis》 2019-02
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Screening and Bioinformatics Analysis of Synovial Differential Genes in Osteoarthritis Based on the GEO Database

CHENG Xiao-ping;ZHENG Wen-wei;NI Guo-xin;  
Objective:To explore the pathogenesis of osteoarthritis by bioinformatics analysis of differential genes between osteoarthritis and normal synovium.Methods:The Gene Chip Database of Synovium was downloaded from the GEO database,and differential genes were screened by GEO2 R.An enrichment analysis was made for GO function and KEGG signaling pathway of differential genes by the DAVID 6.7 database.The PPI network was constructed by String-db database,and key target genes were obtained by Cytoscape 3.6.1 software.Results:A total of 490 differential genes,including 61 up-regulated genes and 429 down-regulated genes,were screened by GEO2 R.They mainly involved in cell differentiation,cell growth,skeletal muscle organ development,cAMP response and other physiological processes.They were mainly concentrated in extracellular matrix receptor interaction,proximal renal tubule resorption of bicarbonate,gastric acid secretion,oxytocin,cyclic adenosine phosphate/protein kinase G,adipocyte factor signaling pathway.Thirteen key target genes were obtained from the PPI network,including FOS,SMARCA4,SOCS3,LEP,FBXO32,MYOD1,TRIM63, SMARCA2,CALB1,MAPK12,ADIPOQ,TTN and EGR1.Conclusion:Bioinformatics can reveal the potential characteristics of gene differences between osteoarthritis and normal joint synovium from different perspectives,and provide new ideas for the treatment of osteoarthritis.
【Fund】: 国家自然科学基金(81572219)
【CateGory Index】: R684.3
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