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《Rheumatism and Arthritis》 2019-02
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Clinical Observation on Treating 41 Cases of Rheumatoid Arthritis of Mixed Heat and Cold Type with Guizhi Shaoyao Zhimu Tang(桂枝芍药知母汤)Combined with Methotrexate

LI Jie-hui;LIN Yan-bin;YU Guang-shu;ZHANG Shou-xiong;LIU You-ying;XU Hong-bin;  
Objective:To observe the clinical efficacy and safety of Guizhi Shaoyao Zhimu Tang(桂枝芍药知母汤)combined with methotrexate in the treatment of rheumatoid arthritis of mixed cold and heat type.Methods:Eighty-two patients with rheumatoid arthritis of mixed cold-heat type in active stage were randomly divided into a treatment group and a control group,forty-one cases in each group.The control group was treated with methotrexate,while the treatment group was given Guizhi Shaoyao Zhimu Tang on the basis of the treatment for the control group.Celecoxib capsules were used in both groups in terms of the degree of pain.The two groups were treated for twelve weeks as a course.The curative effect of TCM syndromes,laboratory indexes and DAS28-ESR scores were observed in both groups.Results:In the treatment group,there were one case of abscission,10 cases of marked effect,28 cases of effective and 2 cases of ineffective,and the total effective rate was 95.00%.In the control group,there were 2 cases of abscission,6 cases of marked effect,18 cases of effective and 15 cases of ineffective,and the total effective rate was 61.54%.There was a significant difference between the two groups(P 0.05).After treatment,the levels of C-reactive protein,erythrocyte sedimentation rate,rheumatoid factor,immunoglobulin(IgG,IgA and IgM)and DAS28-ESR scores in the two groups were significantly lower than those before treatment(P 0.05),and the treatment group was lower than the control group(P 0.05).The number,days and incidence of adverse reactions of celecoxib capsules in the treatment group were significantly less than those in the control group(P 0.05).Conclusion:Guizhi Shaoyao Zhimu Tang combined with methotrexate can further improve the laboratory indicators and joint function of patients with rheumatoid arthritis of mixed coldheat type in active stage,alleviate pain,and have better clinical efficacy and safety.
【Fund】: 福建省卫生系统中青年骨干人才培养项目(2014-ZQN-JC-34)
【CateGory Index】: R593.22
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