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《Radialization Protection》 1993-01
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STUDY ON THE CARCINOGENIC EFFECT OF LONG-TERM DRINKING TRITIATED WATER IN RATS

Zou Shu′ai;Li Maohe;Wang Hui;Lin Suqin(China Institute for Radiation Protection,Taiyuan,030006)  
Induction of tumours was seek in rats drinking water with low dose of tritium for 1.5years.For rats drinking water with 2.22×10~5 Bq of tritiurn/mL(high dose-rate group),the totalturmour incidence was found to be 56% and the malignant tumour incidence to be 34%,for ratsdrinking water with 1.11×10~5 Bq of tritium/mL(low dose-rate group),they were found to be 34and 6.5%,respectively,and for control rats which drinked tap water,these parameters were 22.5and 7.5%,respectively.In the high dose-rate group,more rats(20%)with two types of tumours was observated than in the low dose-rate group(with a frequency of 8.6%).Differences in the totaltumour incidence and in the malignant tumour incidence between high and low dose-rate groups werestatistically significant.For the high dose-rate group,tumours appear about 200 days more early thanthat for the low dose-group.In malignant tumours,fibrosarcoma and adenocarcinoma were more frequent and leukemia,andrhabdomyosarcoma were less.Fibroma and adenoma were frequent benign tumours in thisexperiment.
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