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《Radiation Protection》 2012-01
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Study of Compatibility of Oligo-chitosan and Ginkgo Bilobal Polyprenol Influences on Micronuclear Rates and p53,Gadd45 Protein Expression of Radiated Mice

Guo Jianping 1,Liu Chunhui 2,Wang Yongli 1,Wei Jinping 1,Yang Zhongtian 1(1.China Institute for Radiation Protection,Taiyuan 030006; 2.China National Institute of Standardization,Beijing 100088)  
Study of compatibility of oligo-chitosan and ginkgo bilobal polyprenol(GP) influences on micronuclear rate and p53,gadd45 protein expression of radiated mice.Survival rate and survival time of 30-day-time of radiated mice was studied with the mixture of compatibility of oligo-chitosan and different density of GP.High survival rate of mixture density was screening.Another study on this mixture density was about micronuclear rates of marrow and p53,gadd45 protein of spleen after mice were radiated 12 h.The mixture of 300 mg/kg oligo-chitosan and 5 mg/kg GP could increase remarkably the survival rate and survival time of 30-day-time of radiated mice and degrade micronuclear rates and p53,gadd45 protein expression.Compatibility of oligo-chitosan and GP could effectively raise the survival rate of radiated mice.It could proved initially that the mixture has the function of radiation protection.
【Fund】: 国家“十一五”基础科研项目(A0120060572)
【CateGory Index】: R818
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