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Autophagy Promotes Cell Survival after Gamma Irradiation

Li Junying1,2,Yang Yanli2,Zhang He2,Liu Xiaodan2,Zhang Shimeng2,Zhou Pingkun2(1.Anhui Medical University,Hefei 230032;2.Beijing Insititute of Radiation Medicine,Beijing 100850)  
p53 kockdown and control cells were constructed through lentiviral.Inducing and inhibiting autophagy by serum starvation and 3-MA respectively,and then irradiated cells with γ-ray.Results proves that p53 represses the expression of the autophogy effector-p62/SQSTM1,which possibly explains the new mechanism of p53 inhibition on autophagy.Meanwhile,the induction of autophagy before and after irradiation is demonstrated to be promoting cell survival,which highlights the importance of autophagy in determining the cell fate after irradiation.Further investigation revealed that autophagy inhibition strongly suppresses DNA damage induced cell cycle G2/M arrest which provides new clue to explain the relationship between cell cycle arrest and cell survival.
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