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《RADIALIZATION PROTECTION》 1998-01
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ADAPTIVE RESPONSE INDUCED BY LOW CONCENTRATIONS OF MMC IN HUMAN PERIPHERAL LYMPHOCYTES

Sun Shuqing Wang Bin Jiang Jie(Institute of Radiation,Norman Bethune University of Medical Sciences,Changchun,130021)  
Samples of cultured human peripheral lymphocytes were pre treated with mitomycin C (MMC) in concentrations of 0.01~0.1 μg/mL at 34 h of incubation and then exposed to 1.5 Gy of X rays.Chromosome aberrations,sister chromatid exchanges and micronuclei for these lymphocytes were observed.The results show that the chromosome aberration rates for lymphocytes pre treated with MMC in concentrations of 0.5 and 0.075 μg/mL and the frequences of sister chromatid exchanges for lymphocytes pre treated with MMC in concentrations of 0.01 μg/mL were significantly lower than their own expected values but the rates of micronuclei for lymphocytes pre treated with MMC in concentrations of 0.05,0.075 and 0.1 μg/mL were significantly higher than the expected values.Such results suggest that for studing the cross resistance of lymphocytes to chemicals and ionizing radiation, inconsistent conclusions may be obtained if different endpoints are based on.
【Fund】: 国家自然科学基金
【CateGory Index】: R96
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