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《Radiologic Practice》 2002-01
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A clinical evaluation of electrochemotherapy in liver carcinoma under CT guidance

WANG Peijun,CUI Hengwu,XIN Yuling,et al.Department of Radiology,Changhai Hospital,the Second Military Medical University,Shanghai 200433  
Objective:To evaluate the therapeutic efficacy of electrochemotherapy(ECT)in liver carcinoma.Methods:229 cases of liver carcinoma,among them 163 cases were confirmed by needle biopsy,66 cases were diagnosed by typical clinical symptoms and signs and physical examinations combined with CT and/or MRI manifestations and laboratory findings.According to clinical staging,stage Ⅱ 64 cases,Ⅲ 96 cases,Ⅳ 69 cases.All the patient had underwent ECT.Among them twice therapy 58 cases and 3 times therapy 8 cases.Results:Recent therapeutic effects:1 year follow up CR 47 cases (20.5%),PR 72 cases(31.4%),NC 40 cases(17.5%),PD 19 cases(8.2%).Long term therapeutic effect:The follow up study of 1,2,3 and 5 years,the survival rate was 77.7%,41.5%,29.3% and 9.6% respectively.The CT scan immediately after ECT showed low density necrosis and gas shadow within the tumor.One month after ECT,the CT or MRI presented more of less necrosis and shrinkage of the tumors.One year after ECT,the CT or MRI showed that the tumors disappeared in 47 cases,the tumors were diminished in size and with extensive necrosis in 112 cases,whereas the tumor enlarged in 19 cases.The laboratory findings after ECT showed that the AFP returned to normal in 86 cases,AFP level decreased in 78 cases.During the follow up study of 132 cases with abnormal liver function and 18 cases with ascites,there were no further liver damage and no increase of ascites 2~8 weeks after ECT.Conclusion:ECT is effective for liver carcinoma.It is safe and with less complications.The combined therapy selectively with TACE,PEI and RFT may be more effective in certain cases.
【CateGory Index】: R735.7
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