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《Radiologic Practice》 2005-01
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CT Perfusion and Histopathology Research of Local Cerebral Astrocyte Swelling in Rats

HU Ling,GAO Pei-yi,YUAN Fang,et al.Neuroimaging Center,Tiantan Hospital,Capital University of Medical Sciences,Beijing 100050,P.R.China  
Objective:To evaluate the influence to cerebral local blood flow after astrocyte swelling.Methods:21 male Wistar rats weighting from 250~300g were randomly individed into 3 groups:the contrast group,6h and 24h group.In experimental group,tACPD (the agonist of mGluRs) was microinjected into the right caudatum.After 6 and 24 hours,the rotation per 5 minutes was calculated.Brain water content was measured by a wet/dry weight technique.Dynamic CT perfusion images were achieved from personal computer aided mapping.Histopathology study was performed by both light and electron microscopy.Results:The injection of tACPD induced brain edema after 6h.The swelling of astrocyte could be shown in both light and electron microscopy examination.In perfusion CT images all the animal showed the decrease of rCBF and rCBV,5 of 7 showed the slowdown of MTT and TTP.In brain water content and rotation there were statistically significant difference between operated and contrast group,P0.05.In 24h group all the animals recovered to normal.Conclusion:Astrocytic swelling can induce or deteriorate decrease of cerebral blood flow,but when astrocytic swelling recovered,the cerebral blood flow recovered as well.
【Fund】: 国家自然科学基金资助项目 (30 370 4 2 7) ;; 北京市自然科学基金资助项目 (70 32 0 0 9)
【CateGory Index】: R816.1
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