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《Radiologic Practice》 2010-01
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Perfusion Study of Renal Cell Carcinoma with Dynamic Contrast-enhanced Multislice Spiral CT

CHEN Yan,ZHANG Jin,DAI Jing-rui,et al.Department of Diagnostic Radiology,Cancer Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100021,P.R.China  
Objective:To measure the values of various multi-slice spiral CT(MSCT) perfusion parameters of normal renal cortex,and to study the perfusion imaging features of renal cell carcinoma(RCC),whether there are any differences in the perfusion parameters in different pathology subtypes of RCC.Methods:Dynamic contrast-enhanced perfusion imaging with MSCT was performed prospectively before surgery in 73 cases with histology proven renal cell carcinoma including clear cell RCC(n=65),papillary type RCC(n=3),chromophobic cell RCC(n=5).Blood volume(BV),blood flow(BF),mean transit time(MTT),and permeability surface area product(PS) of tumor and normal renal cortex(including the kidney with tumor and contralateral) were measured and statistically analyzed.Results:The mean BV,BF,MTT and PS of normal renal cortex were(23.53±5.71)ml/100g、(454.32±110.90)ml/(min·100g)、(3.62±1.38)s、(63.95±18.85)ml/(min·100g) respectively.The mean BV,BF,MTT and PS of RCC were(17.17±8.34)ml/100g,(261.96±175.86)ml/(min·100g)、(7.08±3.42)s、(25.07±13.20)ml/(min·100g) respectively.The mean BV,BF,MTT and PS of clear cell RCC were(17.97±8.30)ml/100g,(279.61±177.02)ml/(min·100g)、(6.85±3.39)s、(25.78±12.94)ml/(min·100g) respectively.The mean BV,BF,MTT and PS of papillary type RCC were(4.82±2.93)ml/100g,(52.00±51.77)ml/(min·100g)、(11.74±3.63)s、(11.90±5.12)ml/(min·100g) respectively.The mean BV,BF,MTT and PS of chromophobic cell RCC were(14.22±3.21)ml/100g,(158.49±49.79)ml/(min·100g)、(7.26±1.77)s、(23.69±17.41)ml/(min·100g) respectively.The BV,BF,and PS of RCC were lower than that of normal renal cortex(P0.01),yet the MTT of RCC was longer than that of normal cortex(P0.01).Compared with papillary type RCC,the BV,BF of clear cell RCC were higher and MTT was shorter(P0.05).Compared with chromophobic cell RCC,the BV,BF of clear cell RCC were higher as well(P0.05).The BV,BF of clear cell RCC were higher than that of non-clear cell RCC(P0.05).However,there were no statistical significant differences existed in the parameters in the other pathology subtypes(P0.05).Conclusion:Perfusion differences between renal cell carcinoma and normal renal parenchyma could be directly assessed on dynamic contrast-enhanced MSCT.There were obvious differences showing on the perfusion imaging of different pathological subtypes of renal cell carcinoma.
【CateGory Index】: R737.11
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