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《Radiologic Practice》 2010-01
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Treatment of Peripheral Non-small Cell Lung Cancer by CT-guided ~(125)I Seeds Implantation

DUAN Cheng-zhou,JIANG Ming,FAN Bin,et al.Department of Imaging,Anyang Tumor Hospital,Henan 455000,P.R.China  
Objective:To investigate the value of CT-guided 125I radioactive seeds implantation in the treatment of non-small cell lung cancer(NSCLC).Methods:There were 22 cases with peripheral NSCLS included adenocarcinoma(11 cases),adenosquamous carcinoma(4 cases) and squamous cell carcinoma(7 cases).The diameter of tumor ranged from 3.5~8.0cm.All were diagnosed by CT-guided needle aspiration biopsy of lung.According to three-dimensional treatment planning system(TPS),implantation of 125I seeds permanently in tumor tissues was performed under CT-guidance,the activity of seeds was 0.8mCi.Six cases received adjuvant chemotherapy and two cases had complementary radiotherapy.Therapeutic efficacy was evaluated by follow-up CT scanning.Results:All 22 cases were investigated 6 months after 125I seeds implantation,the satisfaction rate of seeds distribution was 86.36%(19/22 cases),Three cases had complete remission 13.63%(3 / 22 cases);14 cases had partial remission 63.64%(14/22 cases);no change were assessed in 5 cases(22.73%,5/22 cases).Tthe total effective rate was 77.27%(17/22 cases).These patients were followed up for 6~38 months,the 1、2、3 year survival rates were 63.6%(14/22 cases),31.8%(7/22 cases) and 13.6%(3/22 cases) respectively,the median of survival time was 14 months.Conclusion:Implantation of radioactive 125I seeds via percutaneous puncture of lung under CT-guidance had relative satisfactory therapeutic short-term effects and mild injury for non-small cell lung cancer.
【CateGory Index】: R734.2
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【Citations】
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【Co-references】
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1 ZHANG Feng, ZHANG Chang- bao, TIAN Jian-ming, GONG Jing, SUN Gao-feng. Department of Radiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Comparison of therapeutic effects between CT-guided ~(125)I seed implantation and chemotherapy with Gemcitabine for the treatment of unresectable pancreatic carcinoma[J];Journal of Interventional Radiology;2009-09
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