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《Radiologic Practice》 2010-06
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Evaluation study of MRI on non-alcoholic fatty liver disease

ZHANG Zhong-wei,JIN Han-tao,CHEN Ke-min,et al.Department of Radiology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,P.R.China  
Objective:To evaluate the clinical value of MRI on non-alcoholic fatty liver disease(NAFLD).Methods:Forty-five obesity patients underwent in-phase/opposed-phase(IP/OP) magnetic resonance imaging and 1H-magnetic resonance spectroscopy(1H-MRS),we try to find the cut-off point of NAFLD detected by MRI according to the hepatic steatosis severity by CT.Results:Compared with CT,the coefficient correlation of IP/OP MRI hepatic fat fraction(HFF),relative signal intensity decrease(RSID) by MRI and intrahepatocellular lipids of 1H-MRS were-0.951,-0.935,-0.659(P0.01).The hepatic steatosis severity of all methods above were significantly correlate with TG and GGT.In which,RSID was the most correlated parameter(r=0.406,0.457,P0.01).Linear regression analysis was conducted on a log-log scale among the 1H-MRS and ALT,TG and GGT.Conclusion:IP/OP MRI is a convenient,fast,and safe technique,which can detect and quantify liver steatosis.A diagnosis of fatty liver was established with HFF≥9%,RSID≥20%.RSID criterion and intrahepatocellular lipids of 1H-MRS facilitated the correct prediction of the concentration of TG.
【Fund】: 上海市重点学科建设项目资助(S30203)
【CateGory Index】: R445.2;R575.5
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