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《Radiologic Practice》 2010-06
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Diagnostic value of ~(18)F-FDG PET/CT in defining the etiology of fever of unknown origin

ZHANG Bin-qing,ZHANG Yong-xue,WU Tao,et al.Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,P.R.China  
Objective:To assess the diagnostic value of 18F-FDG PET/CT in patients with fever of unknown origin(FUO).Methods:Forty-five patients who were diagnosed as FUO were entered in the study,all those patients underwent 18F-FDG PET/CT whole body imaging.18F-FDG PET/CT imaging results were analyzed based on either histopathology or clinical follow-up.The maximum standardized uptake values(SUVsmax) were measured.The SUVsmax were analyzed with the t test by SPSS 11.0 software.Results:Among the 45 patients,at least one abnormal accumulation of 18F-FDG was found in 35 patients,which led to the final diagnosis of malignant tumor in 9 patients,and infection or inflammatory changes in 26 cases.There was a significanct difference in SUVsmax between malignant lesion and benign lesion(6.09±1.46 vs 2.57±1.33)(t=6.67,P0.05).Among ten patients of negative 18F-FDG PET/CT imaging,4 patients were finally diagnosed as rheumatic diseases,however,the other 6 patients had no final diagnosis.18F-FDG PET/CT imaging contributed to the clinical diagnosis of the cause of an FUO with an accuracy of 77.8%(35/45).Conclusions:In patients with an FUO,18F-FDG PET/CT imaging is valuable to define the etiology of the disease.
【CateGory Index】: R817.4
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