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《Radiologic Practice》 2018-01
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A feasibility study of DCE-MRI in evaluating the effect of sorafenib for inhibitting angiogenesis of implanted liver VX2 cancer in rabbits

PAN Jiang-yang;SHI Gao-feng;WANG Qi;Department of CT & MRI,the Fourth Hospital of Hebei Medical University;  
Objective:Using DCE-MRI parameters to quantitatively evaluate the response of sorafenib targeting treatment for implanted liver VX2 cancer at different time points before and after treatment,and to discuss the feasibility of DCE-MRI in the assessment of therapeutic effect.Methods:Rabbit VX2 liver cancer implantation model was established with tumor mass embedding method.7 days after tumor implantation,30 rabbit models with liver VX2 cancer that had the basically consistent shape and size were screened out through MRI.These rabbits were randomly divided into experimental group and control group(15 rabbits for each).In the experimental group,the rabbits were fed with sorafenib orally,while in the control group,the same amount of 5% glucose was orally fed.DCE-MRI scan was performed before and on the 7 th and 14 th day after treatment.The maximum diameter of tumor and DCE-MRI parameters including microvascular Ktrans,Kep,Ve and Vp at the three time points were recorded.These rabbits were sacrificed afterwards,HE staining and immunohistochemistry staining for micro vascular density and vascular epithelial growth factor(MVD,VEGF)were performed.Results:There were significant differences in Ktrans and Kep values between experimental and control groups(P0.05),yet no significant difference was existed in Ve as well as Vp value of the two groups(P0.05).At different observation time points,the trend of the Ktrans change showed significant difference(P0.05).Significant difference was existed in the maximum diameter of tumor between the two groups on the 14 th day after treatment(P0.05),also in MVD and VEGF value between the two groups(P0.05).Positive correlation was showed between Ktrans value and MVD and VEGF result(r=0.792 and r=0.651,respectively).No correlation was found between other DCE-MRI parameters and MVD or VEGF.Conclusion:DCE-MRI parameters could be used to quantitatively evaluate the response of sorafenib treatment in the anti-vascular formation for rabbit VX2 liver implanted cancer.DCE-MRI parameter Ktrans has positive correlation with MVD and VEGF results,which is an important imaging biomarker to reflect microvascular changes before and after treatment.
【CateGory Index】: R445.2;R735.7
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