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《Radiologic Practice》 2018-01
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The value of biexponential DWI in the differentiation of muscular dystrophy and glycogen storage disease

RAN Jun;LI Xiao-ming;Department of Radiology,Tongji Medical College,Huazhong University of Science and Technology;  
Objective:To investigate the value of a biexponential DWI in the differentiation of glycogen storage disease(GSDs)and muscular dystrophy(MDs).Methods:19 patients with myopathy including 7 patients with GSDs and 12 patients with MDs,and 11 healthy volunteers as controls were recruited in this study.Conventional MR sequences,DWI with b-value ranging from 0 to 1200 s/mm2 was performed on bilateral thigh of all 30 subjects.The biexponential apparent diffusion coefficients(ADC),including ADCstandard,ADCfast,and ADCslowvalues,of these 3 groups were compared.Results:In the control group,the mean ADCstandard,ADCslowand ADCfastof the 7 selected muscles showed no significant standard difference(P0.05).The ADCstandard(P=0.000)and ADCslow(P=0.000)were statistically different among the three groups,while no standard difference was found in ADCfast(P=0.281).The mean ADCstandardvalue of the muscles in GSDs was significantly lower than those in control group(P=0.000)and MDs group(P=0.034).Also the mean ADCslowvalue of the muscles in GSDs group was markedly lower than that of control group(P=0.000)and MDs group(P=0.003).Conclusion:ADC values in biexponential DWI are useful in distinguishing GSDs and MDs.
【Fund】: 国家自然科学基金(81320108013、81571643)
【CateGory Index】: R445.2;R589;R746
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