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《Radiologic Practice》 2018-04
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Research on the effects of various energy combination,reconstruction algorithms,and ROI selection of dual-energy CT on the quantification of iron in rabbit livers

XU Xiao;HUANG Qiu-li;ZHU Xue-jun;Department of Radiology,the First Hospital of Ningbo;  
Objective:To explore the effect of dual-energy CT combination,reconstruction algorithm and ROI selection on quantitative detection of liver iron of rabbits.Methods:32 healthy New Zealand male white rabbits from were injected with dextran iron supplements of 15 mg/kg per week for 16 weeks.Per week two rabbits were accepted dual-energy scanning using 80/l40 kVp and 100/l40 kVp and were sacrificed for pathologic examination for calculating liver iron concentration(LIC).Under80/l40 kVp combination conditions,the filtered back projection(FBP)method and sinogram affirmed iterative reconstruction(SAFIRE)based on the original data with the intensity of 3 were used for reconstruction.The whole-liver ROI method and the small ROI method were used to measure the CT value on virtual iron concentration(VIC)images postprocessed from dual-energy scanning data,and then the CT value of liver on VIC images under different conditions were compared and statistically analyzed for correlation with the LIC using Spearmen correlation analysis.Results:The differences in CT values on the VIC images between two energy combinations and ROI methods were statistically significant(P0.01);while the difference of CT values between VIC images using two reconstruction algorithms was not statistically significant(P0.05).The correlation between CT value of VIC images and LIC of 80/140 kVp,SAFIRE and whole-liver ROI method was better than that of 100/140 kVp,FBP and small ROI method respectively.Conclusion:CT value of VIC images obtained by two energy combinations,reconstruction algorithm and ROI measurement method can indicate liver iron concentration,80/140 kVp and whole-liver ROI method are better,and the measured value will not be affected by different reconstruction algorithms.
【CateGory Index】: R816.5
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