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《Radiologic Practice》 2018-04
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Study on structural changes of brain gray matter in mild nicotine dependence by using magnetic resonance imaging

DONG An-ke;ZHANG Yong;CHENG Jing-liang;Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University;  
Objective:To evaluate brain structure changes in mild nicotine dependence by using MRI and voxel-based morphometry(VBM)study.Methods:77 mild nicotine dependence individuals(FTND6 score)and 37 non-smoking healthy volunteers were scanned with Siemens Skyro 3.0 T magnetic resonance scanner.All subjects underwent routine sequence(to exclude intracranial lesions)and 3 D-MPRAGE sequence MRI examination.SPM8 software based on Matlab was used to analyze the data.The independent sample t test(FWE correction,P0.05,cluster size318 voxels)was used to compare the grey matter volume(GMV)between the smoking group and the control group,and then the Spearman correlation analysis was used to analyze the correlation of the GMV with statistical difference compared with control group and the smoking related indexes.Results:Compared with the control group,the mild nicotine dependent group exhibited decreased GMV in bilateral thalamus and bilateral supramarginal gyrus,and the area with elevated GMV was not found.The GMV of right thalamus,left thalamus and right supramarginal gyrus was significant negatively correlated with smoking index(r=-0.489,-0.500 and-0.312,P0.05),and also negatively correlated with smoking years(r=-0.497,-0.555 and-0.351,P0.05),and the GMV of right thalamus was also negatively correlated with the number to daily smoking(r=-0.260,P0.05).Conclusion:The changes of brain structure of smokers mainly focused on reward related pathways and marginal systems,and the gray matter volume of certain brain regions is related to smoking behavior data.
【CateGory Index】: R163;R445.2
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