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《Radiologic Practice》 2018-04
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Study on structural changes of brain gray matter in mild nicotine dependence by using magnetic resonance imaging

DONG An-ke;ZHANG Yong;CHENG Jing-liang;Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University;  
Objective:To evaluate brain structure changes in mild nicotine dependence by using MRI and voxel-based morphometry(VBM)study.Methods:77 mild nicotine dependence individuals(FTND6 score)and 37 non-smoking healthy volunteers were scanned with Siemens Skyro 3.0 T magnetic resonance scanner.All subjects underwent routine sequence(to exclude intracranial lesions)and 3 D-MPRAGE sequence MRI examination.SPM8 software based on Matlab was used to analyze the data.The independent sample t test(FWE correction,P0.05,cluster size318 voxels)was used to compare the grey matter volume(GMV)between the smoking group and the control group,and then the Spearman correlation analysis was used to analyze the correlation of the GMV with statistical difference compared with control group and the smoking related indexes.Results:Compared with the control group,the mild nicotine dependent group exhibited decreased GMV in bilateral thalamus and bilateral supramarginal gyrus,and the area with elevated GMV was not found.The GMV of right thalamus,left thalamus and right supramarginal gyrus was significant negatively correlated with smoking index(r=-0.489,-0.500 and-0.312,P0.05),and also negatively correlated with smoking years(r=-0.497,-0.555 and-0.351,P0.05),and the GMV of right thalamus was also negatively correlated with the number to daily smoking(r=-0.260,P0.05).Conclusion:The changes of brain structure of smokers mainly focused on reward related pathways and marginal systems,and the gray matter volume of certain brain regions is related to smoking behavior data.
【CateGory Index】: R163;R445.2
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【Citations】
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1 Yang Yan;Nan Yi;Tu Mengwu;Wang Jijiang;Wang Lili;Jiang Yuan;Tobacco Control Office,Chinese Center for Disease Control and Prevention;;Maior finding of 2015 China adults tobacco survery[J];中华健康管理学杂志;2016-02
【Co-citations】
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1 Zhang Ganshen;Luo Lisha;Cui Fangfang;Department of Epidemiology and health Statistics,School of health sciences,Wuhan University;;Analysis of Burden of Cardiovascular Disease Attributed to Risk Factors in China in 1990 and 2015[J];中国卫生统计;2018-03
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7 ZHAO Jie-wen;YAO Peng-tao;LIU Li-xiang;Department of Cardiology,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University;Department of Medicine,Infectious Disease Prevention and Control Hospital of Heilongjiang Province;Department of Management of Social Medicine and Health,School of Health Administration and Education,Capital Medical University;Tobacco Control Office,Chinese Center for Disease Control and Prevention;;The epidemiological investigation on risk factors of nicotine dependence among the smokers in Beijing[J];中华疾病控制杂志;2018-04
8 DONG An-ke;ZHANG Yong;CHENG Jing-liang;Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University;;Study on structural changes of brain gray matter in mild nicotine dependence by using magnetic resonance imaging[J];放射学实践;2018-04
9 WEI Xiao-lin;ZHANG Zheng-ji;HU Yi-he;Suzhou Center for Disease Control and Prevention;;Situation of smoking cessation campaign and its influencing factors analysis in Suzhou during 2006-2017[J];中国健康教育;2018-03
10 HE Yun-yun;WANG Le-qin;ZHANG Zhong-xing;CHEN Hong;LIAN Xue-mei;Innovation Center for Social Risk Governance in Health, Research Center for Medicine and Social Development, School of Public Health and Management, Chongqing Medical University;;Interventions for smoking cessation-related weight gain[J];现代预防医学;2018-06
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