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《Radiologic Practice》 2018-04
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The value of DKI in early diagnosis of hepatolenticular degeneration

LU Qi;WANG An-qin;ZHANG Chun-yun;The First Affiliated Hospital of Anhui University of Chinese Medicine,Image Center;  
Objective:To evaluate the sensitivity and specificity of diffusion kurtosis imaging(DKI)for detecting hepatolenticular degeneration disease(HLD)and compared with conventional magnetic resonance imaging(MRI).Methods:A total of 35 HLD patients in our hospital were enrolled and 30 age-and sex-matched healthy volunteers were recruited as control group.The MRI examination was performed with conventional MR T2-weighted sequence and DKI sequence using a 3.0-Tesla MR system.Thereafter,the data were analyzed with methods of manual ROI using program of ADW4.6,and DKI parameters including mean kurtosis(MK),radial kurtosis(RK)and axial kurtosis(AK),and T2-signal intensity ratio were obtained.Results:Compared to healthy volunteers,MK and T2-ratio of the lenticular nucleus(LN)in HLD group(0.956±0.105 and 0.308±0.210)were higher than those in control group(0.832±0.086 and 0.641±0.473),the difference was significant with P-values less than 0.05.MK,AK,RK and T2-ratio of the bilateral head of caudate nucleus(HCN)in HLD group(0.691±0.123,0.825±0.124,0.597±0.175,0.602±0.440)were all higher than those in control group(0.567±0.066,0.696±0.080,0.497±0.079,0.326±0.225),the differences were significant with P-values less than 0.05.The area under ROC curve(AUC)of MK,T2-ratio in LN was 0.825 and0.708,respectively.The AUC of MK,AK,RK and T2-ratio in HCN was 0.814,0.822,0.670 and0.686 respectively.The differences were significant with P-values less than 0.05 for all DKI indexes.Conclusion:The technique of DKI provides higher sensitivity and specificity than conventional MRI to detect the changes of brian microstructure,it may provide effective value for diagosis.
【Fund】: 国家重点基础研究973发展计划(2010CB530500);; 国家自然科学基金项目(81202768);; 安徽中医学院青年科学临床基金(2011qn022)
【CateGory Index】: R445.2;R742.4
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Chinese Journal Full-text Database 4 Hits
1 TAN Zhao-yuan;YANG Jing;YAN Kai-xin;Medical College of Qinghai University;;The value of diffusion kurtosis imaging in the differential diagnosis of high-grade glioma and solitary brain metastases[J];放射学实践;2017-03
2 WANG Ying-ying;ZHANG Yan;CHENG Jing-liang;Department of MRI,the First Affiliated Hospital of Zhengzhou University;;The value of the diffusion kurtosis imaging in differential diagnosis of benign and malignant breast lesions[J];放射学实践;2017-02
3 LI Gui-dian;XU Ping;ZHOU Xiang-xue;Department of Radiology,Huangpu clinical medical center,The First Affiliated Hospital,Sun-Yat Sen University;;Cranial MRI features and clinical correlation in hepatolenticular degeneration[J];中风与神经疾病杂志;2013-08
4 YAN Liqun,HOU Yaping,GENG Zuojun,et al.Department of Medical Imaging,Second Hospital,Hebei Medical University,Shijiazhuang,Hebei Province 050000,P.R.China;MRI and MRS Features of Wilson Disease[J];临床放射学杂志;2011-06
Chinese Journal Full-text Database 7 Hits
1 XIA Bingqing;LI Xinle;SUN Kun;CHAI Weimin;Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine;;Different models of diffusion-weighted magnetic resonance imaging in differential diagnosis of benign and malignant breast lesions[J];中国癌症杂志;2018-05
2 LU Qi;WANG An-qin;ZHANG Chun-yun;The First Affiliated Hospital of Anhui University of Chinese Medicine,Image Center;;The value of DKI in early diagnosis of hepatolenticular degeneration[J];放射学实践;2018-04
3 LIU Shaowei;ZHU Xin;CUI Weijin;CHEN Xiao;Department of Radiology,Affiliated Hospital of Nanjing University of TCM;;A comparative study on the diagnostic value of DKI and DWI in benign and malignant breast lesions[J];医学影像学杂志;2017-09
4 ZHANG Chunyun;WANG Anqin;WU Hongli;TANG Lanfeng;XU Chunsheng;LU Qi;LI Chuanfu;Anhui University of Chinese Medicine;;Preliminary MRI morphology study on cerebral gray matter in Wilson's disease[J];中国中西医结合影像学杂志;2016-03
5 Jiang Shanshan;Luo Chen;Zhao Rui;Jia Qingyu;Chen Maowei;Department of Infectious Diseases,First Affiliated Hospital,Guangxi Medical University;;Case review of Wilson′s disease and correlation analysis of factors except heredity[J];重庆医学;2016-08
6 QIN Hao-ling;HE Rong-xing;PAN Shun-ping;WANG Ping;PAN Xi-min;HUANG Wei-ling;LI Gui-dian;ZHOU Xiang-xue;LIN Er-jian;CHEN Ying-ming;Department of Radiology,The East Hospital of The First Affiliated Hospital,Sun-Yat Sen University;;Phase value on susceptibility-weighted imaging in cerebral type hepatolenticular degeneration[J];影像诊断与介入放射学;2016-01
7 Yuan Xingya;Xiong Hai;Gan Huatian;West China Fourth Hospital,Sichuan University;West China Hospital,Sichuan University;;Evaluation of Modified Young Scales on Hepatolenticular Degeneration Symptoms and Patients′Quality of Life[J];成都医学院学报;2016-02
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 QU Li-jie;ZHOU Jian-jun;DING Yu-qin;Shanghai Institute of Medical Imaging,Department of Radiology,Zhongshan Hospital,Fudan University;;A pilot study of IVIM and DKI on normal kidney MR[J];放射学实践;2016-10
2 WEI Tao;YIN Hua-bin;MENG Fan-hua;LIN Li-ping;Department of Radiology,The Fifth People's Hospital of Shanghai,Fudan University;;Utility of peritumoral DTI in differentiating high-grade gliomas and cerebral metastases[J];医学影像学杂志;2015-10
3 BA Zhaogui;ZHANG Yumin;NI Xiaoli;YU Zhen;Department of Radiology,the Affiliated Laigang Hospital,Taishan Medical College;;The combination of MRI dynamic contrast enhancement and diffusion weighted imaging in the diagnosis of breast mass lesions[J];实用放射学杂志;2014-10
4 ZHANG Yu-Zhen;LI Fang-Zhen;GAO Yu;Department of Radiology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University,School of Medicine;;Study on diffusion kurtosis imaging in kainic acid induced epilepsy of rat[J];放射学实践;2014-04
5 ZHOU Xiangxue,LI Xunhua,HUANG Haiwei,LIU Bing,LIANG Yingying,ZHU Ronglan,ZHU Jianzhong,LIANG Xiuling,PU Xiaoyong.Department of Neurology,Huang pu area,the First Affiliated Hospital,Sun Yat-Sen University, Guangzhou 510080,China.;Improved Young Scale—a scale for the neurological symptoms of Wilson disease[J];中国神经精神疾病杂志;2011-03
6 LUO Hai-ying,HUANG Biao,LIU Hong-jun,ZHANG Shui-xing,WANG Guang-yi,LIANG Chang-hong(Department of Radiology,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510080,China);Boundary sign and cortex sign on MR in differentiation between solitary brain metastasis and astrocytoma[J];中国医学影像技术;2010-02
7 TANG Yebing,ZHAO Kefu,LU Qi,et al.Section of MRI,the First Affiliated Hospital of Anhui Traditional Chinese Medicine College of Hefei 230031,P.R.China;Analysis of the Correlation between the Clinical Manifestations and MRI Appearances of Brain with HLD[J];临床放射学杂志;2009-09
8 LIU Zhao-yu,SUN Bo,FAN Guo-guang,WANG Xiao-ming,GUO Qi-yong(China Medical University Shengjing Hospital,Shenyang 110004);The Potential Value of Diffusion Tensor Imaging in Differentiating between Advanced Glioma and Solitary Metastasis[J];中国医学影像学杂志;2008-04
9 GUO Yong *, CAI Zulong, CAI Youquan, et al. *Department of Radiology, Naval General Hospital, Beijing 100037,China;Differentiation of benign from malignant breast lesions by apparent diffusion coefficients[J];中华放射学杂志;2001-02
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