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《Radiologic Practice》 2018-04
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The value of DKI in early diagnosis of hepatolenticular degeneration

LU Qi;WANG An-qin;ZHANG Chun-yun;The First Affiliated Hospital of Anhui University of Chinese Medicine,Image Center;  
Objective:To evaluate the sensitivity and specificity of diffusion kurtosis imaging(DKI)for detecting hepatolenticular degeneration disease(HLD)and compared with conventional magnetic resonance imaging(MRI).Methods:A total of 35 HLD patients in our hospital were enrolled and 30 age-and sex-matched healthy volunteers were recruited as control group.The MRI examination was performed with conventional MR T2-weighted sequence and DKI sequence using a 3.0-Tesla MR system.Thereafter,the data were analyzed with methods of manual ROI using program of ADW4.6,and DKI parameters including mean kurtosis(MK),radial kurtosis(RK)and axial kurtosis(AK),and T2-signal intensity ratio were obtained.Results:Compared to healthy volunteers,MK and T2-ratio of the lenticular nucleus(LN)in HLD group(0.956±0.105 and 0.308±0.210)were higher than those in control group(0.832±0.086 and 0.641±0.473),the difference was significant with P-values less than 0.05.MK,AK,RK and T2-ratio of the bilateral head of caudate nucleus(HCN)in HLD group(0.691±0.123,0.825±0.124,0.597±0.175,0.602±0.440)were all higher than those in control group(0.567±0.066,0.696±0.080,0.497±0.079,0.326±0.225),the differences were significant with P-values less than 0.05.The area under ROC curve(AUC)of MK,T2-ratio in LN was 0.825 and0.708,respectively.The AUC of MK,AK,RK and T2-ratio in HCN was 0.814,0.822,0.670 and0.686 respectively.The differences were significant with P-values less than 0.05 for all DKI indexes.Conclusion:The technique of DKI provides higher sensitivity and specificity than conventional MRI to detect the changes of brian microstructure,it may provide effective value for diagosis.
【Fund】: 国家重点基础研究973发展计划(2010CB530500);; 国家自然科学基金项目(81202768);; 安徽中医学院青年科学临床基金(2011qn022)
【CateGory Index】: R445.2;R742.4
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