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《Radiologic Practice》 2018-04
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Prostate imaging reporting and data system version2(PI-RADS v2)in detecting different volume of prostate cancer:based on whole-mount step-section pathology

WANG Hui-hui;HU Juan;HE Qun;  
Objective:To evaluate the diagnostic accuracy of Prostate Imaging Reporting and Data System version 2(PI-RADS v2)for different volume prostate cancer by using whole-mount stepsection slides as standard of reference.Methods:Fifty-two consecutive patients with biopsy-proven prostate cancer(PCa)were included.All patients underwent mpMRI of the prostate,including T2 WI,DWI and DCE.Following radical prostatectomy,all specimens were processed as whole-mount stepsection slides.MR images were interpreted according to PI-RADS v2 by two radiologists(Reader A and B)who were blinded to clinical details and histopathology.Forty-seven tumours of size≥0.5 cm3[any Gleason Score(GS)]and 36 tumours of size0.5 cm3(GS≥3+4)were identified on wholemount pathology.We calculated the proportion of PCa foci on whole-mount pathology correctly identified with PI-RADS v2,stratified by pathologic tumour volume.Results:For reader A,PI-RADS v2 allowed correct identification of 25/25(100%)peripheral zone(PZ)and 22/22(100%)transition zone(TZ)tumours≥0.5 cm3,but only 9/25(36%)PZ and 1/11(9.1%)TZ tumours with a GS≥3+4.For reader B,PI-RADS v2 allowed correct identification of 25/25(100%)PZ and 19/22(86.4%)TZ tumours≥0.5 cm3,but only 13/25(52.0%)PZ and 1/11(9.1%)TZ tumours0.5 cm3(GS≥3+4).Conclusion:PI-RADS v2 could correctly identify 86.4% ~100% of PCa tumors≥0.5 cm3,but was limited for the assessment of tumours0.5 cm3 with GS≥3+4.
【CateGory Index】: R445.2;R737.25
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