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《China Powder Science and Technology》 2017-06
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Preparation of micro-nano drug particles by liquid phase precipitation with reinforced micromixing

CHEN Bo;HUANG Yongpeng;ZHONG Hui;JIAO Jianlan;ZOU Chuanpin;Research Institute of Chemical Defense;  
Micro-nano particles of model drug pentoxyverine citrate were prepared by anti-solvent or reactive precipitation method. The micromixing of liquid phase precipitation was reinforced by micro-channel or high gravity reactor simultaneously. Properties of particles were analyzed. The results show that it is effective of modified reactors to prepare micro-nano particles by reinforced micromixing. Drug particles exhibit100~200 nm flake crystal and remain stable microstructure. The reinforcement is adapted to anti-solvent precipitation as rapid physical process, and high gravity reactor has the highest preparation efficiency.
【Fund】: 国防预先研究项目 编号:LD4C21
【CateGory Index】: TQ460.6
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