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《Acta Materiae Compositae Sinica》 2018-06
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Synthesis,characterization,and swelling behaviors of wheat gluten/poly(sodium acrylate) porous composite hydrogel produced by yeast fermentation

SHI Xiaoning;CHEN Hui;ZHANG Haobo;DAI Hongxia;DUAN Guojian;Key Laboratory of Traditional Chinese Medicine Quality and Standard,Gansu University of Chinese Medicine;Department of Pharmacy,Gansu University of Chinese Medicine;  
Wheat gluten(WG)reacted with acrylic acid(AA)in the promotion of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride(EDC)to produce WG-AA chains.Following,yeast decomposed the starch that existed in WG to produce CO2,which used as pore template to prepare a novel porous WG/poly(sodium acrylic)(PNaA)composite hydrogel(WG/PNaA)via free-radical graft copolymerization of sodium acrylate and WG-AA chains in the aqueous solution.FTIR spectra demonstrate that AA is grafted onto the WG chains,and the composite hydrogel is formed successfully in the presence of cross-linker N,N′-methylene discrylamide(MBA).Field emission SEM(FESEM)also displays that incorporating the proper amount of yeast into the hydrogel matrix can form porous interlinked channels within the composite hydrogel network.The porous WG/PNaA composite hydrogel shows greater equilibrium swelling capacity both in distilled water and in 0.9% NaCl solution,and the Schott's second-order swelling dynamic constant Kisis improved to 5 times compared with non-yeast exited hydrogel.Ritger's semiempirical equation analysis also confirms that the water transport mechanism of the porous WG/PNaA compositehydrogel is non-Fickian diffusion type(n=0.5642),which means,the porous structure of the composite hydrogel is benefit to the water molecules spread quickly at the beginning swelling.The swelling-deswelling behaviors of the porous WG/PNaA composite hydrogel in distilled water-0.9% NaCl solution and in pH 2.2 and pH 7.4 phosphate buffer solution were assessed and the results show that the composite hydrogel exhibits excellent salt,pH-dependent swelling responsiveness after 5 times repeated swelling,which providing apotential application in the field of drug controlled-release.
【Fund】: 甘肃省中药质量与标准研究重点实验室培育基地开放基金(ZYZL16-011);; 甘肃省科技计划资助项目(148RJZA074);; 甘肃中医药大学中青年基金(2305016601)
【CateGory Index】: TB332;TQ427.26
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