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《Chinese Journal of Analytical Chemistry》 2006-03
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Study on Specific Solid Phase Extraction of Anticholinergic Drugs by Molecularly Imprinted Polymers with Structural Analogues as Templates

Guo Yushu, Liu qin, Yang yan, Xie Jianwei(Beijing Institute of Pharmacology & Toxicology, Beijing 100850)  
In order to investigate the molecular recognition mechanism of molecularly imprinted polymer (MIP) and relative influence factors, a series of MIPs were prepared with three structural analog anticholinergic drugs as templates. The specific solid phase extraction and molecular recognition of MIPs were investigated for anticholinergic drugues and their structural analogs, such as neotropine(1116), penequinine(8018), bencynonatine(8021), kemadrine(1113), anisodine(AT_3), chlorphenamine(CPA) by solid phase extraction-high performance liquid chromatography. The results showed that the recognition ability of MIPs was associated closely with the conditions of synthesis, for example, the type and quantity of monomers, cross-linkers and initiators, temperature and the template-monomer ratio. The specific molecular recognition and strong adsorption of MIPs using 1116, 8021 and 8018 as templates, methacrylic acid (MAA) as functional monomer and trimethylolpropane trimethacrylate (TRIM) as crosslinker could be observed for three anticholinergic drugs, with weak or no adsorption for structural analogs. The experiments revealed that the non-specific adsorption of MIPs could mainly result from the interaction of polar groups between MIPs and analytes, for example , hydrogen-band etc. The steric shape complementary between analytes and the recognition sites of MIPs played a key role in the molecular recognition process of MIPs.
【CateGory Index】: TQ460.1
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【References】
Chinese Journal Full-text Database 3 Hits
1 FU Ruo-nong(Department of Chemistry,Beijing Institute of Technoligy,Beijing 100081);Advances on SPE-chromatography in China in recent two years[J];Chinese Journal of Analysis Laboratory;2007-02
2 GUO Yu-shu1,ZHANG Yi1,XIE Jian-wei2(1.Department of Pharmacy,Naval General Hospital,Beijing 100037,China;2.Department of Pharmaceutical Analysis,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);Liquid chromatographic behavior of molecularly imprinted polymers with anticholinergic drugs as template[J];Pharmaceutical Care and Research;2007-04
3 XIAO Hong-tao1,LIAO Zhi2,MO Zheng-ji3 (1 Department of Pharmacy,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610072,China; 2 Department of Gynecology and Obstetrics,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610072,China;3 West China School of Pharmacy,Chengdu 610041,China);Progress in pharmacokinetics of penehyclidine hydrochloride[J];Chinese Journal of New Drugs;2009-10
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YUAN Dong-jun,YANG Li-long,ZHU Wen-bing,et al(Children's Hospital of Hunan Province,Hunan Changsha 410007,China);HPLC determination of sulpiride in human plasma and its pharmacokinetic,and relative bioavailability[J];Journal of Pediatric Pharmacy;2006-03
2 LI Li~1,HU Shu-Guo~1,HE Xi-Wen~(1*),LI Wen-You~1,CHEN Lang-Xing~1,ZHANG Yu-Kui~(1,2*)(1.College of Chemistry,Nankai University,Tianjin 300071,China;2.Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China);Solid-phase Extraction of Active Component of Chinese Traditional Medicine Fisetin by Using Molecularly Imprinted Polymers[J];Chemical Journal of Chinese Universities;2006-04
3 LI Ning,CHEN Xiao-ying (Guangdong College of Pharmacy,Guangzhou 510006,China);Determination of geniposide content in Tanqidiedafengshi ointment by HPLC[J];Journal of Guangdong College of Pharmacy;2006-02
4 LIANG Li-mei~1,PANG Xiao-xiong~2(1.Department of Pharmacy,Guangdong Provincial People's Hospital,Guangzhou 510080,China;2.School of Pharmaceutical Sciences,Guangdong College of Pharmacy,Guangzhou 510006,China);Determination of vitamin B_1 in Anshenbunao oral solution by solid-phase extraction and high-performance liquid chromatography[J];Journal of Guangdong College of Pharmacy;2006-02
5 Ye Jianglei1, Gong Zhenbin 1,2, Shen Aisi2 (1. College of Oceanography and Environmental Science, Xiamen University, Xiamen, 361005; 2. State Key Laboratory for Marine Environmetal Science, Xiamen University, Xiamen, 361005);Capillary gas chromatographic determination of nine pesticide residues in Chinese tea[J];Analytical Instrumentation;2005-02
6 hLIU Zhi-Yong WANG Jun YUE Xia-Li DONG Yuan-Yan (College of Science,Huazhong Agricultural University,Hubei,Wuhan 430070,P.R.China);Determination of Plant Hormones in Rape by HPLC with Changing UV-Vis Wavelengt[J];Chinese Journal of Spectroscopy Laboratory;2006-02
7 CHEN Xiao-qiu (Fujian Environmental Monitoring Center Station , Fuzhou 350003, China);Application Study of SPE Disks and GC/MS/SIM Method in Determining Nitrogen and Phosphorous Pesticides[J];Analysis and Testing Technology and Instruments;2005-02
8 SONG Xiao-lan~1, LIU Qiang~2 (1. Medical Alkaloid Factory of Gansu Province, Wuwai 733006, China; 2. Gansu State Farms Academy of Agricultural Research, Wuwai 733006, China);Determination of Thebaine in Red Poppy by High Performance Liquid Chromatography[J];Analysis and Testing Technology and Instruments;2005-02
9 LI Shao-dan,LI Ming-qiang,MENG Jin-huai(Liuzhou Center for Disease Prevention and Control,liuzhou 545001,China);New Methods for the Determination of Chlorophenols and the Interaction Between Them with Human Serum Albumin[J];Analysis and Testing Technology and Instruments;2005-04
10 LIU Ting-feng, YANG Min-na, LIU Ya-zi,GU Yin, SUN Cheng(State Key Lab of Pollution Control and Resource Reuse, Nanjing University, Nanjing 210093);Recent Advances on Determination of Pyrethroids Residue by ELISA[J];Environmental Science & Technology;2006-04
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 SU Jian-feng,HU Chao-yang,CHEN Jin-xing and CHEN Pei-gui(Fujian Fairreach Food Safety Testing Co.,Ltd,Fuzhou 350015);Rapid determination of residual amounts of 103 pesticides in green soy bean by gas chromatography/mass spectrometry[J];Chinese Journal of Analysis Laboratory;2009-06
2 LU Wan-ping1,YOU Fei-ming2,LI Xin1,WU Fang1,ZHANG Lan1(1.Instrumentation Analysis and Measurement Center of Fuzhou University,Fuzhou 350002;2.Fu jian Provincial Central Inspection Institute,Fuzhou 350002,China);Study on Pretreatment Method for Determination of Organochlorine and Pyrethroid Pesticides Residues in Teas[J];Analysis and Testing Technology and Instruments;2009-02
3 ZHOU Fang, SUN Cheng, LIU Hao;Research on Operation Improvement of Solid Phase Extraction[J];Jiangsu Environmental Science and Technology;2008-01
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