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《Chinese Journal of Analytical Chemistry》 2011-12
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Dummy-template Molecularly Imprinted Polymer for Selective Solid Phase Extraction of Metronidazole in Bovine Serum

TURGHUN Muhammad,ABDUKIREM Kadier,HALIDAN Mamat,NILUPAER Abudukeyoumu(Key Laboratory of Oil and Gas Fine Chemicals,Ministry of Education and Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering,Xinjiang University,Urumqi 830046)  
Metronidazole(MNZ) ester was chosen as a dummy template,methacrylic acid as monomer,ethylene glycol dimethacrylate as crosslinker and chloroform as porogen to synthesize dummy-template molecularly imprinted polymers(MIP) for MNZ.The result of batch rebinding tests showed that imprinting factor of the polymer was 2.02,indicating high recognition ability of the MIP against MNZ.MIP adsorption isotherm was fit to Langmuir adsorption model,therefore it was monolayer adsorption,with maximum binding capacity Qmax of 116 μmol/g and binding constant K of 0.65 L/mmol.The recoveries of MNZ on MIP and nonimprinted cartridges were 97.4% and 44.3% respectively in solid phase extraction(SPE) experiment.However,the analogues of MNZ,MNZ ester and 4-nitrophenol,had recoveries less than 11.6% on both MIP and NIP in SPE,showing the high selectivity of the dummy template MIP against MNZ.The MIP was successfully used for the separation and concentration of MNZ spiked serum sample with mean recovery of 94.5%,which demonstrated that MIP was feasible of pre-treatment of MNZ serum sample without template bleeding.
【Key Words】： Metronidazole Dummy-template Molecularly imprinted polymer Solid phase extraction
【Fund】： 国家自然科学基金(Nos.20765005 21065011);; 新疆大学石油天然气精细化工重点实验室开放课题基金(No.XJDX0908-2010-06)资助
【CateGory Index】： R96
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