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《Chinese Journal of Analytical Chemistry》 2012-09
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Research and Application of Nanostructured Molecularly Imprinted Polymers in Pharmaceutical Analysis

LI Jie1,LIU Tie-Bing2,XIAO De-Li1,DRAMOU Pierre1,ZOU Wen-Yue1,HE Hua1,3 1(Department of Analytical Chemistry,China Pharmaceutical University,Nanjing 210009,China) 2(The Sino-Germany Institute of Agriculture Products Processing Industry, Zhejiang University of Science and Technology,Hangzhou 310023,China) 3(Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University, Ministry of Education,Nanjing 210009,China)  
Nanotechnology is an emerging technology with enormous potential due to their specific structures and properties that differ from traditional materials.Molecularly imprinting is a technique for the preparation of polymers of predetermined specificity based on imitating the way of interaction between antigen and antibody.Compared to conventional molecularly imprinted polymer,nanostructured molecularly imprinted polymer has many advantages: high afinity and selectivity,more accessible sites,fast association kinetics.Thus,nanostructured molecularly imprinting technique receives more and more attention by scientific researchers in recent years.This review covers the synthesis,characterization and latest advances of zero-dimensional(0-D),one-dimensional(1-D) and second-dimensional(2-D) nanostructured molecularly imprinted polymer.Moreover,the application of nanostructured molecularly imprinted polymer in the fields of chiral separation,clinical pharmaceutical analysis,sensor technology and drug residue detection were reviewed.
【Key Words】: Molecularly imprinted polymers Nanostructure Pharmaceutical analysis Review
【Fund】: “新药创制”重大专项(No.2009ZX09301-006);; 浙江省自然科学基金项目(No.Y4110235);; 江苏省普通高校研究生科研创新计划基金(Nos.CXZZ11_0812)资助项目
【CateGory Index】: R917
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