Preparation of Formaldehyde Molecularly Imprinted Polymer Beads and Its Application in Needle Trap Extraction Coupled to Gas Chromatography

LOU Da-wei1,OU Jun-jie2,ZHU Bo1,WANG Ling1,WANG Kun1,WU Wei-yi1(1.Department of Chemistry,Jilin Institute of Chemical Technology,Jilin 132022; 2.CAS Key Laboratory of Separation Sciences for Analytical Chemistry,National Chromatographic R&A Center,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023)  

In this study,the suspension polymerization in mineral oil method using formaldehyde as the template molecule,4-vinyl pyridine(4-VP) as the functional monomer and ethylene dimethacrylate(EDMA) as the cross-linker for the preparation of high selective molecularly imprinted polymer(MIP) beads was described.The prepared beads were spherical and regular with effective recognition sites compared to irregular shaped particles prepared by bulk polymerization.A needle trap extraction(NTE) device was prepared using the MIP beads as adsorption medium,and the device could be coupled with gas chromatography(GC) for the analysis of trace formaldehyde.A series of parameters concerning the effect of polymerization conditions on adsorption property have been evaluated.The results demonstrated that the best adsorption performance of the MIP beads was achieved under the optimized conditions with the reagents ratio(template molecule∶functional monomer∶cross-linker) of 1∶4∶20,pre-polymerization time of 3 h,the pre-polymerization solution to mineral oil ratio of 1∶6.5,and polymerization time of 8 h.The method using a combination of molecular imprinting and NTE technique would possibly provide a new way for the development of novel sample preparation techniques.

【Key Words】： Molecularly imprinted polymer Spherical beads Needle trap extraction Gas chromatography Formaldehyde
【Fund】： 吉林省自然科学基金(No.20101547);; 吉林省科技发展计划资助项目(No.20110345 20080147);; 吉林省教育厅“十一五”科学技术研究资助项目(No.2010173 2008181);; 吉林市科技发展计划资助项目(No.201112207)
【CateGory Index】： O631.3

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