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《Chinese Journal of Analysis Laboratory》 2008-09
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Investigation on a chemiluminescence microfluidic sensor on a chip for determination of chlorpromazine based on molecularly imprinted polymer as recognition elements

HE De-yong1 and ZHANG Zhu-jun2(1.College of Chemistry and Chemical Engineering,Jinggangshan University,Ji′an 343009;2.College of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715)  
A novel chemiluminescence(CL) chlorpromazine microfluidic sensor on a chip based on chlorpromazine-molecularly imprinted polymer on line accumulating chlorpromazine was described.The microfluidic sensor cell with 8 mm long,1 mm wide and 0.5 mm deep was filled with chlorpromazine-MIP for on line selective adsorbing chlorpromazine.The CL reagents,including luminol and ferricyanide,were syringed into the microcell,then the enhanced CL signal was detected.The enhanced CL intensity is linear with chlorpromazine concentration from 0.02 μg/mL to 0.4 μg/mL.The detection limit is 8 ng/mL.The relative standard deviation is less than 5% for determination of 0.2 μg/mL chlorpromazine(n=7).The microfluidic sensor has been successfully applied to the determination of chlorpromazine in human urine.
【Fund】: 科技部攻关(2003BA310A05)项目资助
【CateGory Index】: TP212
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhu Jingping, Chen Hengwu., Fang Qiongjun (Department of Chemistry, Hangzhou University, Hangzhou 310028);Flow Injection Photochemical-Spectrofluorimetric Determination of Chlorpromazine in Pharmaceutical Preparations[J];Chinese Journal of Analytieal Chemistry;1997-05
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 TANG Wen-li,REN Ai-li,LIANG Meng,CHENG Shu-yi(Shandong Province feed inspection institute,ji'nan,shandong 250022);Simultaneous HPLC Determination of Diazepam and Methaqualone in Feed[J];Poultry Science;2006-07
2 Yao Lijuan , Tan Jiayi, Jiang Zhaolin, Xing Limei (Criminal Police College of China, Shenyang 110035);Screening Analysis of Benzodiazepine Medicines and Selected Metabolites in Plasma and Urine Using Gas Chromatography and Electron Capture Detection[J];Chinese Journal of Analytical Chemistry;2004-01
3 DENG Xiao-jun1,GUO De-hua1,ZHU Jian1,WANG Min1,SHENG Yong-gang1,FAN Xiang1,SHENG Mao-qiang2 (1.Shanghai Entry-Exit Inspection & Quarantine Bureau,Shanghai 200135,China;2.College of Food,Shanghai Fisheries University,Shanghai 200090,China);Determination of Benzodiazepines and Metabolites Residues in Foodstuffs of Animal Origin by Liquid Chromatography-Tandem Mass Spectrometry[J];Journal of Instrumental Analysis;2008-11
4 ZHU Xin-le,LIU Qi,LI Dan,WANG Shu-huai,WANG Xia(China Institute of Veterinary Drug Control,Beijing 100081;China);Determination of Diapazem in Swine Urine by Gas Chromatography-Mass Spectrometry[J];Chinese Journal of Veterinary Drug;2009-01
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Guo Xiangqun, Xu Jingou~* Chen Guozhen(Department of Chemistry, Xiamen University, Xiamen, 361005);Photochemical Fluorimetry[J];Chinese Journal of Analytical Chemistry;1991-02
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