Study on solid phase extraction column of nipagin a molecularly imprinted polymer and it's application

ZHOU Qing1,LIU Lan2,ZHANG Zhen-ying1 and Wen Jin-lian*1(1.Department of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006;2.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275)  

To prepare solid phase extraction(SPE) column of molecularly imprinted polymer(MIP) which can present a specific recognition to Nipagin A.Nipagin A MIP was synhesized by bulk polymerization,SPE capability was characterized through equilibrium adsorption experiment and SPE experiment.Eye drops was determined by UV method.The adsorption capability of Nipagin A MIP was stronger than that of Non-MIP.The extraction efficiency by MIP-SPE was 95.1%.The Nipagin A content in eye drops was 0.0265%.Nipagin A MIP presented a good specific recognition to Nipagin A and SPE column showed good selectivity.It can be applied to drug,food and cosmetics test fields.

【Key Words】： Nipagin A Solid phase extraction column Molecularly imprinted polymer
【Fund】： 广东省科技计划项目(2009198);; 国家自然科学基金项目(21005021)资助
【CateGory Index】： TS207.3

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