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《Chinese Journal of Analysis Laboratory》 2018-05
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Determination of roxithromycin residue in environmental water samples using molecularly imprinted solid phase extraction coupled with high performance liquid chromatography

GUO Xue-yan;FU Da-you;YUAN Dong;LI Xue-mei;College of Chemical Engineering,Sichuan University of Science and Engineering;College of Chemical Envionment Engineering,Sichuan University of Science and Engineering;  
Molecularly imprinted polymers( MIPs) for roxithromycin( Rox) were prepared by precipitation polymerization,using Rox as template molecule,methacrulic acid( MAA) as functional monomer,ethylene glycol dimethacrylate( EGDMA) as cross-linker and acetonitrile as porogens. The characterizations of the prepared MIPs and non-imprinted polymers( NIPs) were evaluated by scanning electron microscope( SEM) and equilibrium adsorption experiments. The results showed that the MIPs possessed the specific adsorptivity toward Rox,and the apparent maximum binding capacity( Q_(max)) was19. 03 mg/g. Using the prepared Rox-MIPs as selective adsorbent,the proposed molecularly imprinted solid phase extraction( MISPE) coupled with high performance liquid chromatography( HPLC) was successfully applied to determine Rox residue in water samples. A linear correlation was obtained over a range of 10-50 mg/L( r~2= 0. 9981) with the limit of detection was 0. 28 mg/L( S/N = 3). The spiked recoveries of Rox were 79. 0%-91. 8 % with the relative standard deviations( RSDs) of less than 5%. The proposed method is selective,sensitive and reliable for the analysis of Rox residue in water samples.
【Fund】: 四川省教育厅重点项目(13ZA0123);; 绿色催化四川省高校重点实验室项目(LYJ1405)资助
【CateGory Index】: O657.72;X832
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