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《Humic Acid》 2018-03
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A Preliminary Study on the Effect of Protein Phosphatase 2A Affected by Fulvic Acid and Ginsenoside Rg1

Zhang Caifeng;Liu Zhifan;Song Zhen;Yuan Wen;Li Lin;Deng Chenhua;Liu Cuixian;Taiyuan Normal University Department of Chemistry;Humic Acid Engineering and Technology Research Center of Shanxi Province;Taiyuan Normal University Department of Physics;  
The effects of fulvic acid and ginsenoside Rg1 in notoginsengon respectively acting on protein phosphatase 2(PP2A)were studied by the molecular simulation platform Discovery Studio 4.5.The results showed that ginsenoside Rg1 in notoginseng could promote the activity of PP2A,so as to reduce the hyperphosphorylation of tau protein,in order to prevent Alzheimer disease.Using CDOCKER technology to fulvic acid and ginsenoside Rg1 respectively with PP2A,the combination concluded fulvic acid with PP2A reduce the hyperphosphorylation of tau protein.Ginsenoside Rg1 and PP2A complexes was formed by the docking results analysis.The results of docking with ginsenoside Rg1 and PP2A indicated that fulvic acid could promote the binding of ginsenoside Rg1 to PP2A,thus enhancing the pharmacological activity of PP2A.
【Fund】: “1331山西省腐植酸产业协同创新中心”;; 国家自然科学基金(项目编号51174275);; 山西省自然科学基金(项目编号201601D102010)
【CateGory Index】: R285
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