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Application of Interferon-a and Acyclovir in the treatment of patients with Hepatitis C

Guo Shunming,Li Jingming,Zhang Taihe,et alDepartment of Infectious Disease, 105th Hospital,HeFei,230031 Department of Pathology,General Hospital of Nanjing Branch,PLA  
Twenty-one patients with hepatitis C virus (HCV) RNA positive were divided into three groups.Group l(n-8) subjected tO' interferon-α (IFN-α) and acyclovir (ACV).Group2(n=8) Subjected to IFN-a alone and group 3(n=5)subjected to conventional therapy.IFN-α(3MU) was intramuscularly injected every other day for three months and AGV was used at 0.75/d,IV,for two months.The recovery rate of serum ALT levels of the 3 groups at the end of the regimen were 75%,50% and 40%,.respectively.The negativity rate of HCV RNA were 87.5%,37.5% ?0%,respectively.These results suggested that the combination of IFN-a and ACV is superior in treatment of hepatitis C to IFN-α alone.The HCV RNA converted to negativity in only one case out of five patients with type Ⅱ HCV RNA positive,which demonstrated that type Ⅱ HCV RNA is resistant fo IFN-α
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