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《Journal of Clinical Hepatology》 2000-01
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IMMUNOHISTOCHEMICAL STUDY OF HGV/GBV-C OF HCV-RELATED ANTIGEN EXPRESSION IN THE LIVER TISSUE OF PATIENTS CO-INFECTED WITH HEPATITIS C AND G VIRUSES

Nie Qinghe , HuDarong , Xie Qing ,et al. Tangdu Hospital, Fouth Military Medical University, Xi' an , 710038  
Objective To investigate the distribution of hepatitis G virus(HGV) /GB virus C(GBV-C) related antigens in liver tissue of patients co-infected with hepatitis C and G viruses and discuss the mechanism of liver damage induced by HGV/GBV-C. Methods HGV/GBV-C or HCV-related antigens were detected by immunohistoche-mical methods in paraffin-embeded liver tissue of biopsy from patients with hepatitis. Immunohistochemical assay were performed by HGV/GBV-C NS5 or HCV NS3 monoclonal antibody. Results Among 56 samples,26. 79% (15/ 56)had been detected out HGV/GBV-C NS5 antigen in their liver. 39.29% (22/56)had been detected out HCV NS3 antigen in their liver. The staining signal of HGV/GBV-C NS5 antigen was mainly located in cytoplasm of liver cells and lymphocyte can be seen around positive staining cells. Conclusion HGV/GBVC-related antigens may exist in hepatocyte,HGV/GBV-C minght exerting its role as a target antigen is the course of liver damage. Immunoreaction may take part in the mechanisms of liver damage.
【CateGory Index】: R512.6
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