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《Journal of Clinical Hepatology》 2000-01
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AN INVESTIGATION OF THE STATE OF INFECTION IN BLOOD DONORS WITH HEPATITIS B SURFACE ANTIGEN NEGATIVE AND ANTI-HEPATITIS B CORE ANTIGEN POSITIVE

Tan Fuming, Wang Zhiming, Li Hui, et al. 260th Hospiatl of PLA , Shijiazhuang ,050041  
Objective Sera from 431 HBsAg-negative blood donors were examined for anti-HBc and anti-HBs,and anti-HBc positive donors were furhter tested for IgM anti-HBc by ELISA and HBV DNA by polymerase chain reaction(PCR). Among 431 donors, 196(45. 5%) donors were positive for anti-HBc. Of them, 35( 17. 9%) donors were positive for anti-HBc only and 161(82.1 % ) for both anti-HBc and anti-HBs. Positive rate of IgM anti-HBc in the anti-HBc-positive donors was 32.1 % (63/196), and that in donors with anti-HBc/anti-HBs positive and anti-HBc positive only were 29. 8% (48/161) and 42.95 (15/35) (P 0.1), respectively. Positive rate of HBV DNA was 14.85(29/196) in donors with anti-HBc,and that in donors with anti-HBc positive only and anti-HBC/an-ti-HBs positive were 25. 75(9/35) and 12.4% (20/161) (P 0.05) .respectively. Positive rates of HBV DNA in donors with IgM anti-HBc positive and negative were 39. 7% (25/63) and 3.0% (4/133) (P 0.001) respectively. 154(78.6% ) of donors with anti-HBc were negative or positive only for both IgM anti-HBc and HBV DNA. It is suggested that HBV infection may exist in blood donors with HBsAg negative and anti-HBc positive, especially in donors with IgM anti-HBc positive. The transfusion risk of hepatitis B virus infection could be reduced further if we screen for IgM anti-HBc for better in HBsAg-negative donor.
【CateGory Index】: R181.3
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