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《Journal of Clinical Hepatology》 2003-01
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Experimental Study of Hepatitis A virusemia and in vitro Multiplication

Li Faqing, Jin Hidying, Fang Dexing ,et al. Institute of Military Medicine of Nanjing Command PLA Nanjing 210002  
A methodology of polymerase chain reaction amplification, virus isolation and immunoelectronic microscopy were used to study the patients of hepatitis A and their close contacts, in order to further investigate hepatitis A virus - caused virusemia, the dynamics of the viruses in blood system, and the in vitro multiplication and location of the virus in the peripheral leukocytes and mononu-clear macrophage, and finally to reveal the pathogenesis of the virus. It was shown that after HAV infection, HAV could be isolated directly from serum of the patients, HAAG could be detected in the peripheral leukocytes ,the HAV invaded into peripheral leukocytes at the infection latency, HAV RNA could be detected in the serum immune complex of the patients, and HAV could multplicate in the in vitro cultures of human mononuclerar leukocytes and macrophages.
【CateGory Index】: R512.61
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Li Faqing ,Jin Huiying , Tan Weiguo ,et al . Department of Medical Microbiology Institute of Military Medicine , Nanjing Command , PLA , Nanjing 210002;DYNAMIC DETECTION OF HEPATITIS A VIRUS ANTIGEN OR ANTIBODY IN SERA AND FAECES OF 19 PATIENTS WITH HEPATITIS A[J];Journal of Clinical Hepatology;1999-01
2 Li Faqing, Tan Weiguo, Li Suqin, et al. Institute of military medicine, Nanjing Command, PLA, Nanjing 210002;Detection of HAAg and isolation of HAV from leucocytes of Hepatitis A close contacts[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1997-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Li Faqing ,Jin Huiying , Tan Weiguo ,et al . Department of Medical Microbiology Institute of Military Medicine , Nanjing Command , PLA , Nanjing 210002;DYNAMIC DETECTION OF HEPATITIS A VIRUS ANTIGEN OR ANTIBODY IN SERA AND FAECES OF 19 PATIENTS WITH HEPATITIS A[J];Journal of Clinical Hepatology;1999-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Zheng Ji-shan, Lin Jian-wen, Li Fa-qing (Institute of Military Medicine, Nanjing Command, PLA, Nanjing) Zheng Qi-ge (Nanjing Hospital for Infectious Disease Nanjing) Le Mei-zhao (81th Hospital, Nanjing Command.PLA, Nanjing);Isolation of Hepatitis A Virus in Vitro Directly from Peripheral Blood Mononuclear Cell of Patients with Hepatitis A[J];Virologica Sinica;1988-03
2 Li Faqing, Tan Weiguo, Li Suqin, et al. Institute of military medicine, Nanjing Command, PLA, Nanjing 210002;Detection of HAAg and isolation of HAV from leucocytes of Hepatitis A close contacts[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1997-03
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