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《Journal of Clinical Hepatology》 2003-01
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The serum activity of angiotensin - converting enzyme in diagnosis of AFP - negative HCC patients

Zhou Aiguo, Huang Yubo, Wang Kaihe, et al. Department of gastroenterology, District hospital of Zhaozhuang Municipality, Shandong Province ,277100  
Objective Recently, a number of studies have demonstrated that serum activity of angiotensin- converting enzyme (ACE) significantly decreases in patients with carcinoma of different localizations. There is no information in literature about measuring this enzyme in hepatocullular carcinoma patients. Methods The serum activity of ACE was examined in 38 patients with primary liver carcinoma,21 patients with chronic hepatitis, and 20 healthy subjects. Results The serum activity of ACE increased in patients with cirrhosis (47.77± 10.59,P 0.01),and in chronic hepatitis (38. 35 ± 6.34, P 0.01)and decreased in hepatocellular carcinoma patieats(19.51 ±4.46).There is no difference between AFP- positive (≤200μg/L) and AFP- negative( 200μg/L) patients.Conclusion These results suggests that we can measure serum ACE activity as one of hepatocullular carcinoma marker in diagnosis of the liver disease, especially in AFP- negative cirrhotic patients.
【CateGory Index】: R735.7
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