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《Journal of Clinical Hepatology》 2003-01
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The etiological feature and outcome of patients with severe hepatitis

Sui Yunhua, Xu Jiazhang, Gao Lei, et al.The liver diseases institute,81st hospital of PLA, Nanjing(210002).  
Objective To study the etiologial feature of severe hepatitis. Methods 418 cases of severe hepatitis were collected. The relationship between etiologic type and prognosis of severe hepatitis, and between etiologic models of HBV and prognosis of severe hepatitis were analysed.Results Most of acute severe hepatitis were hepatitis A and hepatitis E. Infection of HBV leads to 92.8% sub - acute severe hepatitis and chronic severe hepatitis. The incidence rate and fatality rate of patients with HbsAg, HbeAb and HbcAb positive were higher in severe hepatitis B patients. There was no significant difference between the fatality rate of patients with single infection of HBV and that of patients with multiple infection of HBV and other type hepatitis virus. Single infection of TTV led to some severe hepatitis. In addtion, 53.6% of patients with HBV DNA positive turned negative naturally after severe hepatitis.Conclusion Severe hepatitis is mainly caused by the infection of HBV, and HBV precore mutant infection is more likely to result in severe hepatitis.
【CateGory Index】: R512.6
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1 Wu Tongchun; Tang Xiaopeng; Zhang Yonghong; et al.(Research Center of Liver Diseases, Second Affiliated Hospital Hunan Medical University, Changsha, Hunan 410011, P. R. China);ANALYSIS OF THE RELATIONSHIP BETWEEN SEVERE VIRAL HEPATITIS AND PATHOGENETIC HEPATITIS VIRUS[J];CHINA JOURNAL OF MODERN MEDICINE;1997-09
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