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《Journal of Clinical Hepatology》 2003-01
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The relationship between the expression of Fas and serum levels of soluble Fas in patients with chronic hepatitis B

Zheng Ruidan, Zhang Yanggen, Rao richun, et al. 175 hospital, Zhangzhou, Fujian 363000.  
Objective To explore the relationship between the expression of Fas and serum levels of soluble Fas in patients with chronic hepatitis B.Method Liver biopsies were studied by immunohistochemistry to determine Fas and serum levels of soluble Fas (sFas) were detected with ELISA in 60 patients with chronic hepatitis B.Results sFas levels in patients with chronic hepatitis B were higher in patients with severe liver injury than in patients with moderate or mild liver injury. There was significant difference among the three groups( P 0.01). The histological activity index was correlated with the degree of expression of Fas and the serum levels of sFas ( P 0.01). Conclusion 1. There was a relationship between the expression of Fas antigen in liver tissue, the serum sFas levels and histological activity; 2. the hepatic apoptosis mediated through Fas antigen may play an important role in pathogenesis of chronic hepatitis B, and decreasing Fas expression contributes to alleviate the degree of hepatic injury.
【Fund】: 福建省漳州市科委资助项目(Z0027)
【CateGory Index】: R512.62
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【Co-references】
Chinese Journal Full-text Database 1 Hits
1 HE Jianfang, ZHOU Jianfang, DAI Licheng, SHI Bainian, WANG Weihong, LU Qunying. Center Laboratory, Huzhou Center Hospital, Zhejiang Huzhou 313000, China;The changes of serum soluble Fas and soluble Fas ligand levels in chronic hepatitis B and its clinical significance[J];Shanghai Journal of Medical Laboratory Sciences;2005-01
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