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《Journal of Clinical Hepatology》 2003-01
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Study on level change of serum type - IV collagen and hyaluranate in chronic liver disease patients.

Ye Yuanhong, Zhang Anzhong. Shan Dong Provincial Hospital 250021  
Objective To study the level change of serum type - Ⅳ collagen (Ⅳ-C) and Hyaluranate (HA) in chronic hepatitis and h'ver cirrhosis patients and their value in diagnosis of liver cirrhosis. Method solid phase - sandwich - enzyme immunoassay was used to recorder the level of Ⅳ -C and HA in 96 chronic HBV hepatitis and liver cirrhosis patients and compared with 20 normal people. Result The serum level of HA and Ⅳ-C was correlated with the degree of hepatic fibrosis. Compared with normal people and mild chronic hepatitis, the level of serum Ⅳ -C and HA in moderate and severe chronic hepatitis and h'ver cirrhosis patients significandy raised (P0.05) .Conclusion The level of serum Ⅳ-C and HA can be used as important diagnostic index in evaluation of the degree of hepatic fibrosis. When they used together, the diagnostic accuracy raised.
【CateGory Index】: R575
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