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《Journal of Clinical Hepatology》 2003-03
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Inhibition of hepatoma cell line SMMC-7721 and induction of its apoptosis by hydroxycamptothecine

Xu Ershu, Xu Qing, Wang Jiejun, et al. Department of Digestion, People's Hospital, Xinchang County, Zhejiang, 312500  
Objective To explore the effect of hydroxycamptothecine on inhibition of hepatoma cell line SMMC-7721 and on induction of its apoptosis. Methods Cell proliferation was detected by MTT; Bcl-2 expression by fluoresce and cell apoptosis by electronic microscopy, flow cytometry and in situ terminal staining. Results The inhibition of hepatoma cell line SMMC-7721 was obvious by hydroxycamptothecine at dose of 3.125μg/mL~100μg/mL; appearance of early cell apoptosis and reduction of Bcl-2 expression were observed at dose of 0.05mg/mL; apoptotic body was at 0.1mg/mL; and apoptotic cells increased as the dose of hydroxycamptothecine increased. Conclusion Hydroxycamptothecine inhibits the proliferation of hepatoma cell line SMMC - 7721 in vitro, which might be induced by the inhibition of Bcl-2 expression.
【CateGory Index】: R735.7
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