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《Journal of Clinical Hepatology》 2008-01
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Clinical and pathological studies on the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome:an analysis of 11 cases

LIU Ze,CAI Shaoping.Department of Infect Diseases,302 Hospital of PLA,Beijing 100039,China  
Objective To explore the clinical and pathological features and responses to therapy of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome.Methods 11 cases with AIH-PBC overlap syndrome and 13 cases with PBC(Scheuer stage 3 and 4),were included,and the emphases was laid upon the clinical manifestations,pathological features and responses to therapy.Results No significant differences in sex,age and course of diseases were found between the 2 groups.In AIH-PBC group,the levels of alanine aminotransaminase,aspartic aminotransaminase,γ-globulin and IgG and the presence of positive antinuclear antibody or antismooth muscle antibody were markedly higher than those in PBC group(P0.05).The pathological findings in the AIH-PBC group included moderate to severe interface hepatitis with plasma cell predominated mixed inflammatory cells infiltration in hepatic and portal tracts,as well as the damage and obvious reactive proliferation of small bile ducts.The liver function tests improved by UDCA treatment in AIH-PBC patients.Conclusion A combined features of both AIH and PBC exists in overlap syndrome,differrent from AIH or PBC alone.The administration of UDCA may benefit.
【CateGory Index】: R575
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Sun Yanling, Zhao Jingmin, Meng Xin et al. Department of Pathology, 302 Hospital of PLA, Beijing 100039, China;Clinical and pathological studies on the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome[J];Medical Journal of Chinese People's Liberation Army;2006-07
2 Gao Jirong,Qiao Ling,Li Tongzeng,et al.Department of Liver Disease,Beijing You An Hospital,Capital University of Medical Sciences,(Beijing 100054,China);Clinical features of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome.[J];Clinical Medicine of China;2006-09
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 CAI Shaoping, LIU Ze. Department of Infectious Diseases , 302nd Hospital of PLA , Beijing 100039,China;Clinical and pathological studies on the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome :an analysis of 16 cases[J];Journal of Clinical Hepatology;2007-04
2 MA Yan,LIN Bing-liang,YAN Ying,ZHANG Xiao-hong,XIE Jun-qiang,GAO Zhi-liang. Department of Infectious Disease,The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,China;Retrospective research on patients with autoimmune liver diseases[J];International Journal of Internal Medicine;2008-09
3 Li Bing, Chen Guofeng, Huang Huihuang.Department Seven of Infectious Diseases, 302 Hospital of PLA, Beijing 100039, China;Clinical features of 50 patients with primary biliary cirrhosis[J];Medical Journal of Chinese People's Liberation Army;2007-05
4 Zhang Yan,Yang Qing,Qu Shaolian etal(Department of clinical laoboratory,Shengli oilfield central hospital);Serum sFas and sFasl content analysis in primary biliary cirrhosis patientc[J];Medical Laboratory Science and Clinics;2009-01
5 Hui-Ai Zhang , Bang-Mao Wang, Yi-Xiang Chang, De- partment of Gastroenterology, General Hospital of Tianjin Medical University, Tianjin 300052, China Ming-Fang Zhang, Department of Pathology, General Hos- pital of Tianjin Medical University, Tianjin 300052, China Yan-Xia Gong, Department of Gastroenterology, Tianjin NanKai Hospital, Tianjin 300100, China;Clinicopathological features of autoimmune hepatic diseases: an analysis of 28 cases[J];World Chinese Journal of Digestology;2008-29
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