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《Journal of Clinical Hepatology》 2008-01
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The Influence Of HBV DNA basal core promoter mutation on serum cytokines and HBV DNA levels in patients with chronic hepatitis B

WU Jianlin,HUANG Liyi,CHEN Maowei,et al.Department of Infections Diseases,First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China  
Objective To probe the influence of HBV DNA basal core promoter mutation on serum cytokines and HBV DNA levels in patients with chronic hepatitis B virus infection.Methods Microplate hybridization-ELISA and Fluorescence Quantitative PCR technology were applied to detect HBV DNA BCP mutation and HBV DNA respectively.The level of IL-2,IFN-γ,IL-4 and IL-10 in sera was investigated by ELISA.Results The IL-2 levels in patients with and without BCP mutation were 61.4±24.7ng/L and 65.1±25.3ng/L;IFN-γ were 82.0±50.1ng/L and 71.8±67.0ng/L;IL-4 were 62.3±46.0ng/L and 59.4±51.0ng/L;and IL-10 were 74.0±88.2ng/L and 81.4±67.0ng/L,respectively(P0.1).The serum HBV DNA levels in HBV DNA BCP mutation group(1×105.82±2.04 copies/ml) was higher than that(1×104.71±1.28 copies/ml) in the non-mutation groups(P0.01).Conclusion The HBV DNA BCP mutation might not change the serum cytokine,but enhance the HBV replication.
【CateGory Index】: R512.62
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