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《Journal of Clinical Hepatology》 2008-01
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The Influence Of HBV DNA basal core promoter mutation on serum cytokines and HBV DNA levels in patients with chronic hepatitis B

WU Jianlin,HUANG Liyi,CHEN Maowei,et al.Department of Infections Diseases,First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China  
Objective To probe the influence of HBV DNA basal core promoter mutation on serum cytokines and HBV DNA levels in patients with chronic hepatitis B virus infection.Methods Microplate hybridization-ELISA and Fluorescence Quantitative PCR technology were applied to detect HBV DNA BCP mutation and HBV DNA respectively.The level of IL-2,IFN-γ,IL-4 and IL-10 in sera was investigated by ELISA.Results The IL-2 levels in patients with and without BCP mutation were 61.4±24.7ng/L and 65.1±25.3ng/L;IFN-γ were 82.0±50.1ng/L and 71.8±67.0ng/L;IL-4 were 62.3±46.0ng/L and 59.4±51.0ng/L;and IL-10 were 74.0±88.2ng/L and 81.4±67.0ng/L,respectively(P0.1).The serum HBV DNA levels in HBV DNA BCP mutation group(1×105.82±2.04 copies/ml) was higher than that(1×104.71±1.28 copies/ml) in the non-mutation groups(P0.01).Conclusion The HBV DNA BCP mutation might not change the serum cytokine,but enhance the HBV replication.
【CateGory Index】: R512.62
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 XING Tong-jing, ZHANG Lian, HOU Jin-ling, ZHANG Ming-xia,VANG Jie, LUO Kang-xian (Department of Infectious Diseases, Nanfang Hospital, First Military Medical University, Guangzhou 510515,China);Influence of HBV invasion into peripheral blood mononuclcar cells on immune response of the patients with chronic hepatitis B[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;2000-02
2 GUO Yabing,DAI Wei,LU Qiaosheng,et al.Department of Infectious Diseases, Nanfang Hospital,The First Military Medical University,Guangzhou,510515;Hepatitis B virus precore/core promoter mutantion in fulminant hepatitis[J];CHINESE JOURNAL OF INFECTIOUS DISEASES;1999-02
3 CHEN Jinjun, HOU Jinlin, WANG Zhanhui, et al. Deprtment of Infectious Diseases, Nanfang Hospital, Guang zhou 510515;Dynamic changes of basal core promoter and pre core mutants of hepatitis B virus in patients with chronic hepatitis B virus infection[J];CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY;1999-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Guo Yabing1; Luo Kangxian1; Lu Qiaosheng1; P. Karayiannis2; Hou Jinlin11Department of Infectious Diseases, Nanfang Hospital, Guangzhou, 510515; 2Department of Medicine, St Mary's Hospital MedicalSchool, London, W2 1NY, UK;Significance of core promoter mutation of hepatitis B virus[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1999-05
2 Huang Liyi, Yu Yanhong.(Department of Infections Diseases,the First Affiliated Hospital, Guangxi Medical University, Nanning 530021 China);A STUDY ON THE RELATIONSHIP BETWEEN SERUM HBeAg AND HBV DNA CONTENTS AND BCP MUTATION IN PATENTS WITH CHRONIC HEPATITIS B VIRUS INFECTION[J];Journal of Guangxi Medical University;2004-05
3 UO Naizhou, WANGWanxiang, MA Da, et al. The First Peoples’ Hospital of Yancheng City, Yancheng 224006, China;Application of HBV gene polymorphism with DNA chip G[J];Jiangxi Journal of Medical Laboratory Sciences;2005-04
4 WU Xiao-man, GUO Hai-bo. (Guangzhou Medical College, Second Affliated Hospital, Guangzhou, Guangdong, 510260);Detection and significance of interleukin 10 levels and HBVDNA in serums from patients with chronic hepatis B .[J];Chinese Journal of Clinical Hepatology;2004-03
5 WU Jian-lin;ZENG Zhi-li;WU Ji-zhou et al.(the First Affiliated Hospital of Guangxi Medical University,the Nursery College of Guangxi Medical University,Nanning 530021,Guangxi,China);A Comparison of Cellular immune status and HBV DNA Levels in patiens with HBeAgnegative and HBeAg-positive chronic hepatitis B[J];Chinese Journal of Clinical Hepatology;2008-04
6 WU Shu-nian(First Hospital of Lanzhou University,Lanzhou,730000,China);Detection and significance of interlerkin 8 and interleukin 10 levels and HBVDNA in serums from patients with chronic hepatitis B[J];Journal of Lanzhou Medical College;2005-01
7 XU Jian-min~1,CHEN Jian~1,WANG Min~2,LIU Fu-guo~1(1.Department of Gastroenterology;2.Department of Health Care,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China);Effects of alcohol on HBV gene mutations in patients with chronic hepatitis B[J];Journal of Shandong University(Health Sciences);2006-11
8 LIU Xin-liang,HE Jin-cai,ZHOU Xiao-mei,ZHAN Bao-e,HE Jin-song(Clinical Laboratory Department,Shenzhen Hospital of Traditional Chinese Medicine,Guangdong Guangzhou 518033 ,China);Analysis of Precore Basal Core Promoter (BCP) Mutation in Patients with Serum Hepatitis B Virus DNA Positive[J];Journal of Medern Laboratory Medicine;2004-06
9 LI Xiumei, LI Shuntian, LIANG Shuren, XU Jian, DAI Chenyang Institute of Tianjin Infectious Disease Hospital, Tianjin 300192, China;Detection of Serum HBV preC A83 Mutant in Hepatitis B Patients[J];Tianjing Medical Journal;2005-06
10 ZHOU Baoqin,WU Xiaofei,WANG Huayu,TANG Jianwu,YANG Aiping Department of Infection, the Affiliated Hai′an Hospitai of Nantong University, Jiangsu 226600,China;Clincal study on mutations of precore and core promoter gene of hepatitis B virus[J];Chinese Journal of Gastroenterology and Hepatology;2006-05
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