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《Anatomy Research》 2018-03
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Effect of Dengzhanshengmai(DZSM)on cognition function,blood glucose and blood lipid level for mouse model of transient ischemic attack

CHENG Xiao;LI Guo-ming;ZHOU Li-hua;SUN Jing-bo;HUANG Yan;LUO En-li;The Brain Disease Centre,Guangdong Hospital of Traditional Chinese Medicine;  
Objective To establish mouse model of transient ischemic attack(TIA)and explore the effects of DZSM on brain cognition function,blood glucose and blood lipid level for mouse model of transient ischemic attack.Methods The TIA mice model were established successfully by injecting t-BHP and living in the hypoxia situation,and the intragastric injection with different doses of DZSM was performed,the mortality rate of mice were counted,brain cognitive function was detected by Morris water maze test and step-down test,the level of the blood lipid and blood glucose of mice were measured by biochemical analysis method. Results DZSM could reduce the mortality of TIA mice,improve the positioning navigation ability,step-down test latency and error times,and have no significant influence on fasting blood glucose,serum total cholesterol and triglyceride in TIA mice. Conclusion DZSM could improve the brain cognitive function of mice with transient ischemic attack,and does not affect the mortality rate and blood glucose and blood lipid levels.
【Fund】: 国家自然科学基金(81303115 81774042 81771353);; 广东省自然科学基金(S2013040016915);; 广州市科技计划(201604020003);; 中国博士后项目(20090460755 BBK42913K09 201003345 BBH429151701);; 香江学者计划资助
【CateGory Index】: R285.5
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