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A Study of Binding Action and Selectivity of Trimethoprim Molecular Template Polymer

ZHOU Jie, HE XiWen, ZHAO Jie, SHI HuiMing (Department of Chemistry, The Key Lab of Functional Polymer Materials for Adsorption and Separation, Nankai University, Tianjin, 300071)  
A molecularly templated synthetic polymer receptor highly selective for trimethoprim was prepared by a molecular selfassembly imprinting technique. The selective binding characteristics of the template polymer were evaluated by Scatchard analysis, 1H NMR study and Ultraviolet spectrometry. The results showed that a class of same binding sites, which could specificially bind to trimethoprim by cooperative hydrogen bonding, were formed in the polymer, and its dissociation constant was estimated to be 22210-4 mol/L. The selective binding experiments for substrates indicated that the polymer gave much higher affinity and selectivity for trimethoprim than for sulfanilamide and sulfapyridine. It is possiple to be a good adsorption and binding material in the selective enrichment and determination of trace trimethoprim in complex biosamples.
【Fund】: 国家自然科学基金 南开大学吸附分离功能高分子材料国家重点实验室资助
【CateGory Index】: R914
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