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《高分子科学(英文版)》 2016-01
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Preparation of Water Dispersible Poly(methyl methacrylate)-based Vesicles for Facile Persistent Antibacterial Applications

Ming-zhi Wang;Tao Wang;Kang Yuan;Jianzhong Du;Department of Polymeric Materials, School of Materials Science and Engineering, Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, Tongji University;Shanghai Tenth People’s Hospital, Tongji University School of Medicine;  
We report a facile strategy for incorporating persistent and effective antibacterial property into a widely used polymer, poly(methyl methacrylate)(PMMA), by copolymerizing methyl methacrylate(MMA) with 2-(tert-butylamino)ethyl methacrylate(TA) in one pot via atom transfer radical polymerization(ATRP). The subsequent self-assembly of the resultant poly(methyl methacrylate)-block-poly[(2-tert-butylamino)ethyl methacrylate](PMMA20-b-PTA15) diblock copolymer affords well-defined water-dispersible vesicles, which can be facilely sprayed on the walls in hospitals for effective inhibition and killing of bacteria. 1H-NMR and gel permeation chromatography(GPC) studies confirmed the successful synthesis of welldefined copolymer. Transmission electron microscopy(TEM), atomic force microscopy(AFM) and dynamic light scattering(DLS) studies proved the formation of vesicles with narrow size distribution. DLS studies revealed the excellent stability of vesicles at various temperatures. Antibacterial tests showed effective antibacterial activities of polymer vesicles against both Gram-positive and Gram-negative bacteria. Moreover, this strategy may be extended for preparing a wide range of polymeric materials for facile antibacterial applications in many fields.
【Fund】: financially supported by the National Natural Science Foundation of China(Nos.21174107 and 21374080);; Shanghai 1000 Plan;; Eastern Scholar Professorship
【CateGory Index】: R943
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