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《高分子科学(英文版)》 2018-10
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An “In Vivo Self-assembly” Strategy for Constructing Superstructures for Biomedical Applications

Man-Zhu Zhao;Dong-Bing Cheng;Zhao-Ru Shang;Lei Wang;Zeng-Ying Qiao;Jing-Ping Zhang;Hao Wang;School of Chemistry, Northeast Normal University;Chinese Academy of Sciences CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology (NCNST);Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology (NCNST);  
The interfacing study of biopolymer and supramolecular chemistry enables a better understanding of fundamental biochemical processes and the creating of new high-performance biomaterials. In this review, we introduced an "in vivo self-assembly" strategy which means in situ construction of functional self-assembled superstructures in specific physiological or pathological conditions in cell, tissue or animal levels that exhibit diverse biomedical effects. By using this strategy, unexpected phenomena and insights, e.g,assembly/aggregation induced retention(AIR) effect have been demonstrated where the self-assembled nanostructures showed extraordinary enhanced accumulation and retention of therapeutics in targeted sites.
【Fund】: financially supported by the National Natural Science Foundation of China(Nos.21704020 21374026 and51573032);; the National Science Fund for Distinguished Young Scholars(No.51725302);; financial support from the China Postdoctoral Science Foundation(No.2017M620707)
【CateGory Index】: O641.3;R318
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